{"id":"W4416085335","doi":"10.1093/neuonc/noaf201.1397","title":"EXTH-64. Allogeneic CAR-DNT cell therapy to overcome spatial heterogeneity in glioblastoma","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fonds Wetenschappelijk Onderzoek","keywords":"Chimeric antigen receptor; Cytotoxicity; Cytotoxic T cell; Cell therapy; In vitro; Glioblastoma; Immunotherapy; CD19; Antigen; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000661105,0.0002525127,0.0002625626,0.0002403782,0.00007724445,0.0001826973,0.0001257434,0.0001600706,0.0008836224],"category_scores_gemma":[0.00003078578,0.00006970738,0.0001136434,0.0001520088,0.0001141735,0.00009056632,0.0001604488,0.000309698,0.0002124097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986746,"about_ca_system_score_gemma":0.0002324932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107528,"about_ca_topic_score_gemma":0.001493592,"domain_scores_codex":[0.9999522,0.000004425796,0.000002734117,0.000009930066,0.00001184668,0.0000188599],"domain_scores_gemma":[0.9999833,0.000001891136,0.000003701178,0.000002694462,0.000002176765,0.00000625371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000341514,0.0002802972,0.0003671978,0.00008603414,0.00001187089,0.0001258245,0.00003350295,0.0006042585,0.9854058,0.0003371262,0.0001993783,0.01220731],"study_design_scores_gemma":[0.000210218,0.005354339,0.005347985,0.00001822356,0.00007761144,0.001081305,0.00004579817,0.003148661,0.9736495,0.0001539824,0.01090552,0.000006768895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945645,0.001487555,0.001785332,0.0000503815,0.00003349398,0.00007597077,0.0001272878,0.00007010793,0.001805252],"genre_scores_gemma":[0.9967225,0.0007069916,0.0007201874,0.00002362664,0.000006851525,0.0000328666,0.0001682894,0.000007788103,0.001610867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107528,"threshold_uncertainty_score":0.002955973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02928261303002896,"score_gpt":0.3507666771826927,"score_spread":0.3214840641526637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}