{"id":"W4416085345","doi":"10.1093/neuonc/noaf201.1068","title":"PTHP-11. Assessment of Molecular Tools in Pediatric, Adolescent and Young Adult Meningioma Highlights Unique Biology and Underscores the Need for Lifespan Precision in Neuro-Oncology","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Meningioma; Young adult; DNA methylation; Cohort; Brain tumor; Precision medicine; Methylation; Clinical Practice","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001712647,0.0004290651,0.0004016348,0.0009024703,0.000298491,0.001387586,0.0004828863,0.000505446,0.001429747],"category_scores_gemma":[0.004839814,0.0002171242,0.0004496724,0.0005905373,0.0002736003,0.0007760888,0.0006678512,0.001025006,0.0006125397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006496917,"about_ca_system_score_gemma":0.0006097304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004268256,"about_ca_topic_score_gemma":0.008670528,"domain_scores_codex":[0.999478,0.0001304071,0.00004899018,0.0001639365,0.0001235048,0.00005506287],"domain_scores_gemma":[0.9977034,0.0007409554,0.000785986,0.0001533917,0.0003534825,0.0002628302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004122587,0.00005007333,0.9351739,0.0001263164,0.0001698186,0.000404577,0.0001565882,0.001627959,0.006653312,0.0002470911,0.001563536,0.05341454],"study_design_scores_gemma":[0.00002487954,0.0004612056,0.9595394,0.0001622254,0.0001864497,0.002627904,0.0004882381,0.01326224,0.01167318,0.001421096,0.01012204,0.00003123962],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760434,0.006131279,0.00654943,0.001416184,0.0001079189,0.00006242507,0.005015154,0.0003063377,0.004367778],"genre_scores_gemma":[0.9924912,0.00101947,0.004281545,0.0001580375,0.00003424832,0.00003257486,0.001120449,0.00002604774,0.0008365044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004268256,"threshold_uncertainty_score":0.009057462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481008278023731,"score_gpt":0.3387759911833526,"score_spread":0.3139659084031153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}