{"id":"W4416085364","doi":"10.1093/neuonc/noaf201.1178","title":"IMG-99. Volumetric tumor growth rate (TGR) modeling predicts clinical outcomes in patients with Grade 2, isocitrate dehydrogenase 1/2 mutant (mIDH1/2) glioma receiving vorasidenib or placebo in the Phase 3 INDIGO trial","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Glioma; Placebo; Isocitrate dehydrogenase; Confidence interval; Proportional hazards model; Multivariate analysis; Clinical trial; Astrocytoma; Oligodendroglioma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002569256,0.0005051026,0.0005704684,0.00037883,0.00007500449,0.000715721,0.0005377021,0.0003790711,0.0008111205],"category_scores_gemma":[0.00238692,0.0002102693,0.000802579,0.0003069712,0.0002037951,0.0003473231,0.0002826826,0.0007705017,0.000315173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008648629,"about_ca_system_score_gemma":0.000440769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968272,"about_ca_topic_score_gemma":0.001858459,"domain_scores_codex":[0.9995961,0.0002478567,0.00001389337,0.00006721242,0.00004748064,0.00002753147],"domain_scores_gemma":[0.9993023,0.0003531664,0.0001650354,0.00007993539,0.00003562099,0.00006396234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.04978327,0.001746686,0.4941854,0.0003306582,0.001685167,0.0001849814,0.0002883579,0.3129682,0.02809095,0.001613682,0.004557319,0.1045653],"study_design_scores_gemma":[0.001073946,0.008416357,0.1649621,0.00003098636,0.0005194913,0.000309235,0.0001001431,0.8079065,0.01227957,0.001523326,0.002812916,0.00006551234],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929752,0.0006479968,0.003996083,0.0001660047,0.00001279939,0.000051945,0.001189466,0.0001259877,0.0008345361],"genre_scores_gemma":[0.9969988,0.0001000938,0.001470504,0.00004493872,0.000005596974,0.00004068623,0.001040849,0.00001714159,0.0002814706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002569256,"threshold_uncertainty_score":0.01358771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054604603426565,"score_gpt":0.3550506624591637,"score_spread":0.3145046164248981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}