{"id":"W4416085530","doi":"10.1093/neuonc/noaf201.1066","title":"PTHP-09. High-resolution proteomic analysis of medulloblastoma clinical samples identifies MYC immunohistochemistry as a powerful outcome predictor outperforming genetic amplification detection","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Dalhousie University; University of Toronto; BC Children's Hospital; BC Cancer Agency; University of Manitoba; BC Cancer Foundation; Spinal Cord Injury BC; McMaster University","funders":"","keywords":"Medulloblastoma; Immunohistochemistry; Biomarker; Targeted therapy; Wnt signaling pathway; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116083,0.0003892755,0.000495736,0.000631498,0.0002468221,0.001028622,0.0004274935,0.0003242565,0.001912789],"category_scores_gemma":[0.001891677,0.000205555,0.0004167117,0.0005054884,0.0002762316,0.0004120386,0.0008708801,0.0005567444,0.0008059196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004495074,"about_ca_system_score_gemma":0.0004815331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001906309,"about_ca_topic_score_gemma":0.002900559,"domain_scores_codex":[0.9995213,0.00009740235,0.00004397958,0.0001680481,0.0001227774,0.00004661264],"domain_scores_gemma":[0.9993054,0.0001639508,0.0002147219,0.00009002452,0.0001239992,0.0001020241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003934651,0.0003310001,0.7063072,0.0004016416,0.001066898,0.0006773325,0.0001346711,0.004332671,0.2042419,0.0003401228,0.007544813,0.07068721],"study_design_scores_gemma":[0.0001540149,0.001043753,0.8661705,0.00005803016,0.0004368334,0.00225859,0.0002007582,0.04172461,0.0780376,0.0009098166,0.008955328,0.00005007314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847866,0.0007861183,0.00448519,0.0003553671,0.00004515505,0.00006705945,0.008008681,0.0003653583,0.001100436],"genre_scores_gemma":[0.9837893,0.0002503404,0.005993365,0.00008254698,0.00002269631,0.00004964544,0.009100072,0.00005116852,0.0006608675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912789,"threshold_uncertainty_score":0.006398976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02558082819929499,"score_gpt":0.3532461570822411,"score_spread":0.3276653288829461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}