{"id":"W4416087605","doi":"10.7554/elife.108802","title":"Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Nucleosome; Histone; Acetylation; Chromatin; Promoter; Histone code; Histone H3; CpG site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271399,0.0001753039,0.0001915668,0.0004868871,0.0001756523,0.0003180005,0.0001844508,0.0002346933,0.001124035],"category_scores_gemma":[0.0001587926,0.0002130892,0.0002149232,0.0003690879,0.0002873243,0.0001528861,0.0003367515,0.0002594433,0.0003877875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130612,"about_ca_system_score_gemma":0.0001067952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391853,"about_ca_topic_score_gemma":0.002192823,"domain_scores_codex":[0.9998885,0.000006176861,0.000005804217,0.00004086008,0.00003018398,0.00002835955],"domain_scores_gemma":[0.9998435,0.00001936492,0.0000610939,0.00001289938,0.00001597252,0.00004714069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001438836,0.000005051766,0.01010588,0.00004387961,0.00002248185,0.00007987515,0.00005120612,0.00005061409,0.9874006,0.0001162842,0.00004899276,0.001931376],"study_design_scores_gemma":[0.00001532474,0.00009176623,0.4974177,0.00001134623,0.00004483886,0.0007036472,0.0001168855,0.0006300776,0.4982331,0.0003928553,0.002330449,0.00001197405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936277,0.001630056,0.003354082,0.0000438817,0.000008685831,0.000003610104,0.0004356594,0.00008628909,0.0008100796],"genre_scores_gemma":[0.9966156,0.0003234378,0.001084244,0.00003726737,0.000006876908,0.000004248676,0.0008707963,0.00001878179,0.001038682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391853,"threshold_uncertainty_score":0.003760219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005265401992635455,"score_gpt":0.2135234704827572,"score_spread":0.2082580684901218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}