{"id":"W4416088080","doi":"10.1136/jitc-2025-sitc2025.0599","title":"599 The MATRiX trial: a multicenter, randomized, phase II study of ATR inhibition (via tuvusertib) with or without avelumab in patients with advanced anti-PD-(L)1-refractory merkel cell carcinoma","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; EMD Serono","keywords":"Avelumab; Merkel cell carcinoma; Merkel cell; Phase (matter); Carcinoma; Matrix (chemical analysis)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107175,0.001612231,0.002307205,0.0003568226,0.0004165886,0.001252986,0.0008479123,0.001191467,0.005707141],"category_scores_gemma":[0.000735597,0.0005626919,0.001427741,0.0003897305,0.00104959,0.001209239,0.0003774434,0.003089476,0.001393005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006342573,"about_ca_system_score_gemma":0.0008868906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009222127,"about_ca_topic_score_gemma":0.002527247,"domain_scores_codex":[0.9996929,0.0001372928,0.00001287104,0.00005922356,0.00002200086,0.00007567553],"domain_scores_gemma":[0.999698,0.00006433885,0.00005192085,0.00002754352,0.00001295482,0.0001451827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9166513,0.01073252,0.001388934,0.0006507755,0.001181271,0.00009608648,0.00009991508,0.001300328,0.01554125,0.0005680589,0.003804941,0.04798462],"study_design_scores_gemma":[0.9116752,0.08280786,0.002221754,0.00001811028,0.0003216146,0.00006515429,0.00003364276,0.0006471628,0.0007716247,0.0002134665,0.001201542,0.00002293616],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886661,0.003156141,0.0006454577,0.0009414018,0.0005146405,0.001451997,0.001305543,0.000175033,0.003143689],"genre_scores_gemma":[0.9830215,0.002835782,0.001737758,0.001425344,0.000422152,0.002098694,0.002242756,0.00005818496,0.006157862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005707141,"threshold_uncertainty_score":0.01909232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008445985497383852,"score_gpt":0.2557856591224185,"score_spread":0.2473396736250346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}