{"id":"W4416088080","doi":"10.1136/jitc-2025-sitc2025.0599","title":"599 The MATRiX trial: a multicenter, randomized, phase II study of ATR inhibition (via tuvusertib) with or without avelumab in patients with advanced anti-PD-(L)1-refractory merkel cell carcinoma","year":2025,"lang":"","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; EMD Serono","keywords":"Avelumab; Merkel cell carcinoma; Merkel cell; Phase (matter); Carcinoma; Matrix (chemical analysis)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001126137,0.0009083009,0.001761094,0.0002716682,0.0004994302,0.00009144561,0.0003389264,0.000365462,0.000003908071],"category_scores_gemma":[0.0006708242,0.0005756602,0.0002078062,0.0005087985,0.001287876,0.00005950131,0.0003077934,0.0005217223,0.000001085465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009737405,"about_ca_system_score_gemma":0.0009331505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004711548,"about_ca_topic_score_gemma":0.0006278888,"domain_scores_codex":[0.9949163,0.0008212024,0.001640591,0.001224723,0.0006735336,0.0007236748],"domain_scores_gemma":[0.9969831,0.0001711179,0.001003905,0.0009711562,0.0005204179,0.0003503375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8134071,0.01469401,0.09199566,0.001211576,0.001617564,0.0001031917,0.007952673,0.0009279042,0.06653886,0.00000538191,0.0001302934,0.001415757],"study_design_scores_gemma":[0.834671,0.01616473,0.01931166,0.0009238446,0.001470272,0.000007919419,0.00336169,0.0003380604,0.1225362,0.000009960785,0.0003110644,0.0008935704],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895447,0.002711401,0.0000909936,0.0001539182,0.0003975426,0.006942994,0.00007080926,0.00002375109,0.00006391357],"genre_scores_gemma":[0.9984477,0.0002306495,0.0003058451,0.0001201992,0.00008836195,0.0002941786,0.00009550431,0.00009297585,0.0003246117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.072684,"threshold_uncertainty_score":0.9996695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008445985497383852,"score_gpt":0.2557856591224185,"score_spread":0.2473396736250346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}