{"id":"W4416096008","doi":"10.1080/19490976.2025.2573045","title":"Microbiota shape the colon epithelium controlling inter-crypt absorptive goblet cells via butyrate–GP R109A signalling","year":2025,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of Environmental Health Sciences; Universidade Estadual de Campinas; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Centre National de la Recherche Scientifique; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Quadram Institute Bioscience; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Butyrate; Microbiome; Epithelium; Population; Intestinal epithelium; Short-chain fatty acid; Gut flora; Receptor; Function (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004407781,0.0003960918,0.0003991944,0.0001060757,0.0004027048,0.0001263048,0.0006282297,0.0003434207,0.0001115805],"category_scores_gemma":[0.00003182878,0.0003150983,0.0002500819,0.0001966658,0.0002390899,0.000007715579,0.0003009622,0.0003635763,0.0001347488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007001937,"about_ca_system_score_gemma":0.0002272306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001615838,"about_ca_topic_score_gemma":0.0001903533,"domain_scores_codex":[0.9978456,0.0001795058,0.0005356991,0.0006823253,0.00007542306,0.0006814005],"domain_scores_gemma":[0.9988972,0.00007927098,0.0002029298,0.0005187351,0.0002113518,0.00009051906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001944487,0.00009661223,0.000143109,0.00007844658,0.0001803173,0.000004383491,0.0001969349,0.00006263633,0.986846,0.0001248082,0.01106286,0.001009399],"study_design_scores_gemma":[0.001134074,0.000186602,0.0002433747,0.000138193,0.00008418173,0.00001960786,0.0002935425,0.0002261468,0.9092232,0.00014928,0.08795103,0.0003507503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741006,0.005886912,0.01419829,0.00238595,0.001030219,0.0009564694,0.0002394067,0.0000561696,0.001145972],"genre_scores_gemma":[0.9888158,0.0007111497,0.0009008086,0.004370423,0.0002893198,0.0000325365,0.0001494194,0.00004624399,0.004684332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07762283,"threshold_uncertainty_score":0.9999301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00543211662118034,"score_gpt":0.2356679797004687,"score_spread":0.2302358630792884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}