{"id":"W4416102523","doi":"10.1136/thorax-2025-btsabstracts.180","title":"S174 Reduction of exacerbations according to type 2 inflammatory biomarkers with dupilumab treatment in patients with chronic obstructive pulmonary disease","year":2025,"lang":"","type":"article","venue":"","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Exacerbation; COPD; Dupilumab; Eosinophil; Placebo; Exhaled nitric oxide; Eosinophil cationic protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004182512,0.0005597381,0.001577159,0.000448266,0.0002325218,0.0006483334,0.000321868,0.0009281872,0.007366722],"category_scores_gemma":[0.00566306,0.0002357361,0.004239837,0.0004843654,0.0003669348,0.0003643916,0.0002611806,0.0009800671,0.0005113678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006670665,"about_ca_system_score_gemma":0.0009324414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386467,"about_ca_topic_score_gemma":0.003455035,"domain_scores_codex":[0.9979296,0.001350318,0.00016859,0.0001740209,0.0002745079,0.0001029894],"domain_scores_gemma":[0.9964031,0.001954338,0.0009056312,0.0001486586,0.0003487705,0.0002395833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.5363419,0.001811492,0.07478002,0.008286374,0.02615874,0.0002419539,0.0001836045,0.002332981,0.01157139,0.0007765176,0.02721511,0.3103],"study_design_scores_gemma":[0.2372299,0.100943,0.5819632,0.001711696,0.0297697,0.0009546715,0.0002258264,0.007065473,0.008848112,0.001945781,0.02914088,0.0002017705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8817029,0.08678044,0.001382034,0.004617671,0.002224477,0.002016919,0.00737825,0.0002361767,0.01366114],"genre_scores_gemma":[0.9895655,0.003658422,0.001079223,0.001746182,0.0007427419,0.000447076,0.001402232,0.0000214722,0.001337231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007366722,"threshold_uncertainty_score":0.02464414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009084287806166455,"score_gpt":0.2660782046100416,"score_spread":0.2569939168038752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}