{"id":"W4416103183","doi":"10.1136/thorax-2025-btsabstracts.107","title":"S101 Impact of dupilumab in patients with chronic obstructive pulmonary disease with cardiovascular or metabolic comorbidities: BOREAS and NOTUS trials","year":2025,"lang":"","type":"article","venue":"","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Dupilumab; Exacerbation; Placebo; COPD; Population; Vital capacity; Pulmonary function testing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003128809,0.0008869742,0.002065063,0.0002612205,0.0004543905,0.001402705,0.0005553452,0.002262612,0.01272971],"category_scores_gemma":[0.004245208,0.000304189,0.00472331,0.0003872924,0.0004165481,0.0009620796,0.0004597183,0.001951284,0.00114434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006555482,"about_ca_system_score_gemma":0.001124085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159496,"about_ca_topic_score_gemma":0.005505618,"domain_scores_codex":[0.9985683,0.0009184435,0.000145644,0.0001035781,0.0001476735,0.0001162536],"domain_scores_gemma":[0.9983841,0.0006081612,0.000420167,0.0001238428,0.000203467,0.0002602589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7798267,0.002384953,0.00349862,0.0206035,0.01569948,0.0002238394,0.0001592564,0.0007538976,0.00752436,0.00154487,0.03228062,0.1354998],"study_design_scores_gemma":[0.8474271,0.06169768,0.02198314,0.00437511,0.01413072,0.0004618118,0.0001653293,0.0009458146,0.001699029,0.001929715,0.04507402,0.0001104714],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5838732,0.2766392,0.002289462,0.0197075,0.008215509,0.01393109,0.03548811,0.0005982962,0.05925762],"genre_scores_gemma":[0.9346359,0.02685615,0.002946262,0.01094943,0.00247499,0.00655094,0.009150447,0.00005894129,0.006376857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01272971,"threshold_uncertainty_score":0.04258507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01785010402262421,"score_gpt":0.2994292076711335,"score_spread":0.2815791036485092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}