{"id":"W4416106154","doi":"10.1093/cid/ciaf604","title":"A Phase 3, Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Conjugate Vaccine, in Pneumococcal Vaccine-Naïve Adults 18–64 Years of Age at Increased Risk of Pneumococcal Disease, STRIDE-8","year":2025,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Immunogenicity; Pneumococcal conjugate vaccine; Randomized controlled trial; Streptococcus pneumoniae; Immune system; Pneumococcal infections; Young adult; Streptococcaceae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002020949,0.001592127,0.002174644,0.0002885798,0.0004523722,0.001054021,0.0007811941,0.00167171,0.006016086],"category_scores_gemma":[0.002204727,0.0005709577,0.001638537,0.0002872715,0.0008771752,0.0008899418,0.000375433,0.002641012,0.0008263844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006321851,"about_ca_system_score_gemma":0.001517798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103475,"about_ca_topic_score_gemma":0.002000868,"domain_scores_codex":[0.9993673,0.000331712,0.00004321043,0.0001277329,0.00005395136,0.00007604923],"domain_scores_gemma":[0.9987679,0.0002999163,0.0004139761,0.00007716141,0.0001118684,0.0003292297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9830207,0.005517757,0.0006177876,0.000560175,0.0005884779,0.00002953212,0.0000412555,0.0001730646,0.0025383,0.00007103305,0.0005547313,0.006287151],"study_design_scores_gemma":[0.9336473,0.06378443,0.001370076,0.00002939266,0.000236319,0.00002913871,0.00001253216,0.0002153382,0.00029118,0.00007237717,0.0003052396,0.000006754486],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860172,0.003113358,0.0006506484,0.0004436696,0.0005013227,0.005911384,0.001488654,0.0001270837,0.001746751],"genre_scores_gemma":[0.9839345,0.00198437,0.001810783,0.001121309,0.0003601901,0.006779599,0.001844586,0.00002744721,0.002137216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006016086,"threshold_uncertainty_score":0.02012581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228320203791658,"score_gpt":0.3478409971982961,"score_spread":0.3250089768191303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}