{"id":"W4416115859","doi":"10.1093/jimmun/vkaf273","title":"Ubiquitination of MHC class II molecules regulates B-cell development and response to antigens in mice","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Institute for Research in Immunology and Cancer; Institut National de la Recherche Scientifique; Montreal Clinical Research Institute; Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health; Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse","keywords":"Ubiquitin; Germinal center; Ubiquitin ligase; Antigen; Lipid raft; Immune system; Effector; Endocytosis; MHC class II","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002946356,0.0007986653,0.0003537406,0.001391835,0.0003628029,0.0007401018,0.0005498191,0.0009343343,0.002344225],"category_scores_gemma":[0.000197847,0.0005888504,0.0005281518,0.0002952058,0.0006155141,0.0004973552,0.0005108626,0.001522021,0.001232178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007456715,"about_ca_system_score_gemma":0.0003027961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005419754,"about_ca_topic_score_gemma":0.0006130324,"domain_scores_codex":[0.9993991,0.00009160947,0.00007042354,0.0001733527,0.0001158215,0.0001497167],"domain_scores_gemma":[0.9995037,0.00003376918,0.0001787479,0.00005042199,0.00002869399,0.0002045902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005614506,0.0001590787,0.0004531314,0.00004080015,0.00001201152,0.0001125282,0.00002936587,0.00007644529,0.9964293,0.0003287929,0.00008966702,0.001707476],"study_design_scores_gemma":[0.0002021251,0.001168036,0.01714335,0.00004825256,0.0001037952,0.001051755,0.00008505958,0.001456724,0.970598,0.0005489113,0.007569722,0.00002432386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889225,0.002910463,0.003033414,0.0002711528,0.00005836673,0.00009236566,0.001318846,0.0003859765,0.003007009],"genre_scores_gemma":[0.9846619,0.001630521,0.002761777,0.0002245952,0.00003702821,0.000155809,0.001176315,0.0001495638,0.009202423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002344225,"threshold_uncertainty_score":0.007842183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007224564797548107,"score_gpt":0.2252693102089895,"score_spread":0.2180447454114414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}