{"id":"W4416118211","doi":"10.1016/j.ymthe.2025.11.010","title":"CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; University of Alberta; Institute for Research in Immunology and Cancer","funders":"Stem Cell Network","keywords":"CD33; Myeloid leukemia; Myeloid; Immunotherapy; Haematopoiesis; Epitope; Cord blood; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001835879,0.0002746641,0.0002335591,0.00008383422,0.0001267854,0.0000514675,0.0003087483,0.0001962612,0.00001856421],"category_scores_gemma":[0.00003841642,0.0002776118,0.0002490901,0.0001522085,0.00004722188,0.000002979341,0.00005228152,0.0001057677,0.000002966151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001102189,"about_ca_system_score_gemma":0.00005908556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001394,"about_ca_topic_score_gemma":0.000007037526,"domain_scores_codex":[0.9987041,0.000041482,0.0002740095,0.0004586412,0.000121625,0.0004001577],"domain_scores_gemma":[0.9992144,0.00001927301,0.00006156672,0.0005362593,0.0001072937,0.00006117459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002154193,0.00008463042,0.0003255755,0.00001894303,0.0003107104,0.00000471872,0.00003258336,0.0002506678,0.9393098,0.0001877126,0.0008620223,0.05839726],"study_design_scores_gemma":[0.002535024,0.000443356,0.0003812638,0.00002464624,0.00002502604,0.000007691757,0.00003335251,0.0001134599,0.8800148,0.0003953407,0.115761,0.0002650039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7281643,0.01452801,0.2549081,0.0003770931,0.0006064099,0.0006373323,0.00001980168,0.00005556156,0.0007034244],"genre_scores_gemma":[0.9914242,0.001741899,0.003533536,0.001531154,0.0003199987,0.0001968849,0.0001391723,0.00006648227,0.001046673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2632599,"threshold_uncertainty_score":0.9999676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006278468461614668,"score_gpt":0.3042968627949602,"score_spread":0.2980183943333455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}