{"id":"W4416118935","doi":"10.1016/j.isci.2025.113952","title":"G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Polyadenylation; Gene isoform; Alternative splicing; Three prime untranslated region; Messenger RNA; RNA; Cleavage and polyadenylation specificity factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004138304,0.0002548691,0.0002137561,0.0001804145,0.0001600735,0.000296046,0.0001637716,0.0002929832,0.002390361],"category_scores_gemma":[0.0003327308,0.0001671772,0.000214815,0.00007342689,0.000296916,0.0001757803,0.0002485749,0.0005934372,0.0005626909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996169,"about_ca_system_score_gemma":0.0001295484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819735,"about_ca_topic_score_gemma":0.0005477181,"domain_scores_codex":[0.999666,0.0001006989,0.00003182673,0.00008710081,0.00007609583,0.00003823144],"domain_scores_gemma":[0.9996374,0.0001423565,0.0001035848,0.0000433354,0.00001996009,0.00005347856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005247397,0.00001869724,0.00004821178,0.00001470492,0.000002943016,0.00001883927,0.0000105611,0.00007703294,0.9986705,0.0001641911,0.00002534341,0.0008964723],"study_design_scores_gemma":[0.000009559351,0.0002334203,0.0007561558,0.00000440456,0.000007602614,0.00009610445,0.000008182591,0.001326737,0.995833,0.00009558362,0.001623778,0.000005402651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892287,0.0006487318,0.006502395,0.00009776701,0.00006667613,0.0000404989,0.0001616812,0.0002061576,0.003047458],"genre_scores_gemma":[0.9935125,0.0001455517,0.003849153,0.00008356172,0.00001178893,0.00001521068,0.0002194521,0.00006251904,0.00210024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002390361,"threshold_uncertainty_score":0.007996559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411569941777123,"score_gpt":0.3172930175611426,"score_spread":0.3031773181433713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}