{"id":"W4416122039","doi":"10.1186/s40478-025-02152-3","title":"Alzheimer’s disease PSEN-2 N141I mutation reveals altered and shear-sensitive brain endothelial cell-like phenotype in human iPSC-derived models","year":2025,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Efflux; Phenotype; Blood–brain barrier; Induced pluripotent stem cell; Monocyte; In vitro; Shear stress; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002459399,0.000246602,0.0002961155,0.0002056546,0.0009319329,0.00009046117,0.0005831895,0.00007739094,0.000009616032],"category_scores_gemma":[0.0006287898,0.0002315132,0.00006890935,0.0004876053,0.000571457,0.0002788167,0.0007530825,0.0004448097,0.000007503871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002437336,"about_ca_system_score_gemma":0.00004659437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002627478,"about_ca_topic_score_gemma":0.00002588012,"domain_scores_codex":[0.9972098,0.00132928,0.0004189035,0.0005964509,0.0001554804,0.0002900374],"domain_scores_gemma":[0.9972606,0.00108567,0.0001690498,0.001296984,0.00008493552,0.0001027495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001181606,0.0002346995,0.0007597823,0.00001690015,0.00001164745,0.00007133881,0.001929491,0.0001269126,0.9770704,0.0170909,0.001161498,0.001408262],"study_design_scores_gemma":[0.007812549,0.0007274073,0.7061285,0.0002990765,0.0008140492,0.0001933298,0.002895763,0.0207354,0.08542631,0.1573908,0.01491826,0.00265855],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672902,0.0007340981,0.0007974149,0.01453375,0.0003455557,0.0009613784,0.0001519434,0.0002556706,0.01492997],"genre_scores_gemma":[0.9920224,0.0006278202,0.0005132494,0.006369064,0.00002750275,0.0001084438,0.00002387537,0.00002017345,0.0002874489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8916441,"threshold_uncertainty_score":0.9440834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07105294511563005,"score_gpt":0.3126009048674526,"score_spread":0.2415479597518226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}