{"id":"W4416122738","doi":"10.1007/s00277-025-06723-1","title":"From pharmacokinetic-guided FVIII prophylaxis to low-dose Emicizumab prophylaxis: a pilot study revealed a flush of hope","year":2025,"lang":"en","type":"article","venue":"Annals of Hematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; McMaster University","keywords":"Regimen; Breakthrough bleeding; Hematology; Retrospective cohort study; Hemarthrosis; Coagulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003657653,0.0002915904,0.001299225,0.0006448799,0.00005933863,0.000007880365,0.0003394346,0.0001269823,0.0002339369],"category_scores_gemma":[0.0006734557,0.0002211394,0.0001578582,0.000939768,0.0002035648,0.00004376899,0.0002555141,0.000299408,0.00006649483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002352068,"about_ca_system_score_gemma":0.000384168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006268294,"about_ca_topic_score_gemma":0.00002709726,"domain_scores_codex":[0.9972082,0.0002838598,0.0009491838,0.0005674709,0.0004735724,0.0005176814],"domain_scores_gemma":[0.9979608,0.0002734396,0.0001833389,0.0007658752,0.0005941272,0.0002224073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02167285,0.02900539,0.1935937,0.003891743,0.00411019,0.002129521,0.004581766,0.000009567143,0.6659797,0.0005229317,0.04728687,0.02721573],"study_design_scores_gemma":[0.01447711,0.04047054,0.04991511,0.001367482,0.0003631389,0.00008894506,0.001093019,0.00006028738,0.8900884,0.0009831273,0.000707863,0.0003849712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879624,0.001416837,0.00001506567,0.005287047,0.0001526044,0.003153594,0.00003959662,0.00004957883,0.001923282],"genre_scores_gemma":[0.9971575,0.0001107897,0.0004079108,0.0005390574,0.00007025022,0.0002161854,0.00002410164,0.00002884548,0.001445424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2241087,"threshold_uncertainty_score":0.9017804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08272565726646962,"score_gpt":0.4121387801383494,"score_spread":0.3294131228718798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}