{"id":"W4416131702","doi":"10.21203/rs.3.rs-7474344/v1","title":"Directed Differentiation of Human Pluripotent Stem Cells to Functionally Mature Lung Alveolar Cells.","year":2025,"lang":"","type":"preprint","venue":"Research Square","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Hospital for Sick Children; Canadian Lung Association","keywords":"Lung; Progenitor cell; Induced pluripotent stem cell; Stem cell; Regeneration (biology); Alveolar cells; Alveolar Epithelium; Cellular differentiation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003825599,0.0001922627,0.0001217659,0.0001891631,0.00008655691,0.0002711691,0.0001554262,0.0002223349,0.002801817],"category_scores_gemma":[0.0004138071,0.0001113758,0.000166959,0.0002053675,0.0001177408,0.00009402818,0.0002582685,0.0005454383,0.001374161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147744,"about_ca_system_score_gemma":0.0002102176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002721227,"about_ca_topic_score_gemma":0.0005664825,"domain_scores_codex":[0.9998664,0.00003107172,0.00001479354,0.00001762074,0.00005261859,0.00001757681],"domain_scores_gemma":[0.9998825,0.00004514979,0.0000130439,0.00001831094,0.0000247141,0.00001637695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001139562,0.00002844574,0.0003145261,0.0001271859,0.00001335042,0.0001076143,0.0000772298,0.0004377278,0.9782019,0.003508816,0.001578132,0.01549129],"study_design_scores_gemma":[0.00006457091,0.0002015557,0.001725403,0.00002736455,0.00003019839,0.0003661151,0.00003750738,0.001988671,0.9567532,0.001429051,0.03737107,0.000005339847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7176629,0.009064009,0.197647,0.001207564,0.001039091,0.0007840851,0.01187637,0.0009800091,0.05973889],"genre_scores_gemma":[0.9007894,0.004076449,0.05552433,0.000417387,0.00007550877,0.0003258438,0.008993297,0.0001850222,0.02961272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002801817,"threshold_uncertainty_score":0.00937295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06584046381985532,"score_gpt":0.4185307300674553,"score_spread":0.3526902662476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}