{"id":"W4416133596","doi":"10.3390/pathogens14111137","title":"Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis","year":2025,"lang":"en","type":"article","venue":"Pathogens","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Mendelian randomization; Autism spectrum disorder; Gut flora; Metabolome; Genome-wide association study; Autism; Genetic association; Linkage disequilibrium; Microbiome; Metabolite","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04549665,0.002304214,0.003887349,0.00360004,0.001871417,0.001753055,0.00255047,0.001776733,0.009275285],"category_scores_gemma":[0.07094027,0.0009856378,0.009846145,0.003690557,0.001553141,0.001240354,0.002754919,0.002272319,0.0007579228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009545847,"about_ca_system_score_gemma":0.002727536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01026306,"about_ca_topic_score_gemma":0.004582806,"domain_scores_codex":[0.9359461,0.04676593,0.00236882,0.01019991,0.003155026,0.001564151],"domain_scores_gemma":[0.9587787,0.02940718,0.003111017,0.006808718,0.001226091,0.0006684007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.02040248,0.0009495195,0.6483853,0.00262281,0.102688,0.006097252,0.001399327,0.02982577,0.007601895,0.03500665,0.008799456,0.1362216],"study_design_scores_gemma":[0.007754913,0.00671724,0.2245681,0.0009606938,0.07492208,0.006878611,0.001099468,0.596894,0.003483044,0.05758153,0.0186025,0.0005379684],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5664846,0.006329272,0.4134135,0.001562621,0.0004722591,0.002252753,0.005482475,0.001558583,0.002443895],"genre_scores_gemma":[0.8927994,0.0009817724,0.09873801,0.0003315265,0.0001078017,0.002883352,0.00233315,0.000225213,0.00159989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04549665,"threshold_uncertainty_score":0.2406121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00366160916984353,"score_gpt":0.2308997504043864,"score_spread":0.2272381412345428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}