{"id":"W4416134429","doi":"10.1136/thorax-2025-btsabstracts.380","title":"P199 Mepolizumab improves and sustains asthma control and lung function in patients with severe asthma independent of baseline blood eosinophil count in the real world: results from REALITI-A at 2 years","year":2025,"lang":"","type":"article","venue":"","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AllerGen","funders":"","keywords":"Mepolizumab; Eosinophil; Lung function; Asthma; Baseline (sea); Pulmonary function testing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009806331,0.0004393776,0.0007871497,0.0001811243,0.000211073,0.0006534368,0.0004368773,0.0005443489,0.001825415],"category_scores_gemma":[0.0006518389,0.0002131973,0.001167268,0.0002427193,0.0002928801,0.0004369938,0.00027515,0.0008373724,0.0004614708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003999136,"about_ca_system_score_gemma":0.0004078458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009109817,"about_ca_topic_score_gemma":0.001449365,"domain_scores_codex":[0.9996338,0.0001422473,0.00004369734,0.00006111553,0.00007067996,0.00004840661],"domain_scores_gemma":[0.9992736,0.0001088759,0.0003182651,0.00008591278,0.00005391498,0.0001594051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4597739,0.03226082,0.204541,0.001584495,0.005279694,0.0006046486,0.0003778326,0.001190722,0.09124814,0.0001679814,0.004134648,0.1988362],"study_design_scores_gemma":[0.04438164,0.2641844,0.6735834,0.00008389453,0.00198244,0.0009910674,0.0001504269,0.001633038,0.009670251,0.0001007733,0.003164177,0.00007457537],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974437,0.001373353,0.00008383446,0.00007844269,0.00001506015,0.00008482454,0.0004756023,0.00002317658,0.0004219402],"genre_scores_gemma":[0.9978796,0.0004391522,0.0002685962,0.0001651948,0.00003955546,0.0000971117,0.0006972785,0.000004184702,0.0004091783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825415,"threshold_uncertainty_score":0.006106675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003477605954276257,"score_gpt":0.2211680383478157,"score_spread":0.2176904323935395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}