{"id":"W4416139854","doi":"10.1093/neuonc/noaf201.1873","title":"TMIC-120. Investigating EGFRvIII mRNA LNP vaccine-induced re-programming of the GBM TME using the 10x Genomics Visium HD platform","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care; University of Calgary","funders":"","keywords":"Tumor microenvironment; Immune system; Transcriptome; Cytotoxic T cell; Immunotherapy; Messenger RNA; Cancer; Cancer immunotherapy; Cancer vaccine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430821,0.0002653353,0.000171995,0.0001784334,0.00007560014,0.0002130128,0.0001351255,0.0002340809,0.001117724],"category_scores_gemma":[0.00006809241,0.0001337293,0.000199896,0.0001119057,0.000200843,0.0001671514,0.0001679668,0.0003388172,0.0002642731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002807453,"about_ca_system_score_gemma":0.0001698857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006640191,"about_ca_topic_score_gemma":0.0007760729,"domain_scores_codex":[0.9999342,0.000005286892,0.000001941864,0.00002051631,0.00002098236,0.00001709247],"domain_scores_gemma":[0.9999634,0.000005663432,0.00001350481,0.000002869009,0.000007194758,0.000007482792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005349881,0.00001107522,0.0001104516,0.00001743815,0.000001898855,0.00000862967,0.000009938704,0.0001863956,0.9984102,0.00005108009,0.00004399572,0.001095456],"study_design_scores_gemma":[0.000004175234,0.0002296573,0.001449578,0.000002599027,0.000006982447,0.00003127671,0.00001528077,0.002937944,0.9941342,0.00003070147,0.001153413,0.000004240099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862698,0.0004564101,0.01044849,0.00006987112,0.00002725593,0.00004313454,0.0008693226,0.0003672521,0.001448544],"genre_scores_gemma":[0.9773524,0.0005646858,0.01566453,0.0001048174,0.000007743657,0.0001350911,0.001422378,0.0001593047,0.004589105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117724,"threshold_uncertainty_score":0.003739178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05131430558547638,"score_gpt":0.3314214146380487,"score_spread":0.2801071090525723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}