{"id":"W4416139920","doi":"10.1093/neuonc/noaf201.1690","title":"TIP-30. Molecularly-guided phase 2 umbrella trial for children and young adults with newly-diagnosed high-grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG): CONNECT TarGeT (Targeted pediatric HGG therapy) trial in progress","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Young adult; Temozolomide; Clinical trial; Glioma; Everolimus; Immunotherapy; Brain tumor; Precision medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001252226,0.0008678648,0.0008203929,0.0002867423,0.0003573298,0.0009601168,0.0007248431,0.001046174,0.0044156],"category_scores_gemma":[0.000824903,0.0002673974,0.0007172307,0.0002968159,0.0005416189,0.0008335137,0.0005392226,0.002630342,0.001168733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072363,"about_ca_system_score_gemma":0.001385764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008774081,"about_ca_topic_score_gemma":0.005501116,"domain_scores_codex":[0.9996163,0.0001848659,0.00001278642,0.00006577485,0.00004731932,0.00007300874],"domain_scores_gemma":[0.9995667,0.00004738028,0.00009374364,0.00003718899,0.00002593315,0.0002288971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3075952,0.01989861,0.02565768,0.002584327,0.003069977,0.001076043,0.0006024904,0.01303903,0.0614314,0.006943993,0.1107798,0.4473215],"study_design_scores_gemma":[0.6316803,0.2059926,0.05358751,0.000620553,0.001456416,0.002415039,0.0002634879,0.01115651,0.01441389,0.006866839,0.07140412,0.0001427631],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9497638,0.008232196,0.00208102,0.004808147,0.0004856498,0.004636755,0.01210498,0.000644395,0.01724321],"genre_scores_gemma":[0.9449548,0.004288883,0.007690681,0.006394761,0.0002583817,0.006465912,0.01885011,0.0001475906,0.01094885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0044156,"threshold_uncertainty_score":0.01477164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916596600940383,"score_gpt":0.3146626158717512,"score_spread":0.2954966498623473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}