{"id":"W4416140204","doi":"10.1093/neuonc/noaf201.0554","title":"CTNI-58. UPDATED RESULTS OF PHASE 3 STELLAR TRIAL: EFLORNITHINE IMPROVES OVERALL SURVIVAL AND BLINDED INDEPENDENT CENTRAL REVIEW DETERMINED PROGRESSION FREE SURVIVAL IN PATIENTS WITH RECURRENT WHO 2021 GRADE 3 IDH-MUTANT ASTROCYTOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Manitoba","funders":"","keywords":"Lomustine; Eflornithine; Progression-free survival; Astrocytoma; Clinical endpoint; Overall survival; Anaplastic astrocytoma; Log-rank test","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006524242,0.0006964201,0.002112136,0.0005777401,0.0006359699,0.001601582,0.00113496,0.001160839,0.002680527],"category_scores_gemma":[0.006517381,0.0003779723,0.002298637,0.0006481984,0.0005622577,0.0007883027,0.0005245563,0.001416032,0.0007943802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001566485,"about_ca_system_score_gemma":0.002737893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002362051,"about_ca_topic_score_gemma":0.009417753,"domain_scores_codex":[0.9970289,0.001722413,0.0003190942,0.0003792058,0.0004053079,0.000145054],"domain_scores_gemma":[0.9947786,0.0007806929,0.002027264,0.0005730055,0.001196968,0.0006434037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7400261,0.002929229,0.02221118,0.006008246,0.01036324,0.0002104293,0.0003965277,0.00138451,0.02330663,0.0004718957,0.02251901,0.170173],"study_design_scores_gemma":[0.716153,0.0910868,0.1096204,0.001780335,0.02307252,0.000918728,0.000266634,0.003075809,0.009616991,0.001042386,0.04312392,0.0002425517],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9130568,0.03909083,0.001485773,0.002869235,0.001018589,0.009483998,0.01824446,0.0003409519,0.01440939],"genre_scores_gemma":[0.9452562,0.00773955,0.005037357,0.002995613,0.0006707773,0.006484514,0.0265709,0.0001386073,0.005106481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006524242,"threshold_uncertainty_score":0.03450388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02273987129967692,"score_gpt":0.3294818697341074,"score_spread":0.3067419984344305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}