{"id":"W4416140227","doi":"10.1093/neuonc/noaf201.1168","title":"IMG-89. Volumetric (3D) compared with traditional bidirectional (2D) assessment in patients with Grade 2, isocitrate dehydrogenase 1/2 mutant (mIDH1/2) glioma receiving vorasidenib or placebo in the Phase 3 INDIGO trial","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Placebo; Concordance; Glioma; Kappa; Correlation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002152785,0.00077674,0.001463159,0.0003104027,0.0001275306,0.0009811653,0.0005271713,0.0005059454,0.001418808],"category_scores_gemma":[0.001817017,0.0003550048,0.001442671,0.0003203206,0.0004679586,0.0005976913,0.0003470582,0.001240582,0.0003151949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008251592,"about_ca_system_score_gemma":0.0004597987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005853664,"about_ca_topic_score_gemma":0.001904745,"domain_scores_codex":[0.9989086,0.0007200108,0.00004069021,0.0001533217,0.0001022904,0.0000750262],"domain_scores_gemma":[0.9994038,0.0001727534,0.0002342357,0.00006449337,0.00003478791,0.00008987375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7725915,0.003138345,0.04664772,0.001070151,0.004940841,0.00008050536,0.0002053502,0.006932429,0.01761623,0.0005201977,0.00280977,0.143447],"study_design_scores_gemma":[0.2287151,0.3224051,0.3637801,0.0003738018,0.01320347,0.0006329596,0.0004033309,0.04088309,0.01606836,0.002679455,0.01055816,0.0002970682],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992191,0.004366377,0.0006335682,0.0002813647,0.00009632357,0.0002148463,0.000761497,0.00009498181,0.001360083],"genre_scores_gemma":[0.9973965,0.0005021488,0.0007261407,0.0001886937,0.00004509091,0.0002216538,0.0005108649,0.00001330413,0.0003957096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002152785,"threshold_uncertainty_score":0.01138514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03688663681545817,"score_gpt":0.3277187121549753,"score_spread":0.2908320753395171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}