{"id":"W4416140351","doi":"10.1093/neuonc/noaf201.0557","title":"CTNI-61. A PHASE 2 STUDY OF ERDAFITINIB IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH-WILD TYPE GLIOMA WITH FGFR-TACC GENE FUSIONS: SAFETY RUN-IN COHORT RESULTS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cohort; Tolerability; Adverse effect; Glioma; Performance status; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002499528,0.001736864,0.002110932,0.0004071885,0.0005294288,0.001062127,0.0007498808,0.001075903,0.002019184],"category_scores_gemma":[0.001304896,0.0006164385,0.001785876,0.0003960821,0.0008690883,0.0009876338,0.0004692356,0.002940363,0.0008573041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001111123,"about_ca_system_score_gemma":0.002102674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119708,"about_ca_topic_score_gemma":0.003316427,"domain_scores_codex":[0.9992939,0.0003131117,0.00003930135,0.0001397971,0.00008047167,0.0001332953],"domain_scores_gemma":[0.9990043,0.000106769,0.0001978494,0.0001244374,0.00008630946,0.0004803229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6589232,0.0760631,0.04058444,0.0009473438,0.003292767,0.001094894,0.0007263561,0.004895851,0.08453628,0.0004753594,0.008302034,0.1201584],"study_design_scores_gemma":[0.3230738,0.6134787,0.04506665,0.00004626065,0.001247053,0.001397071,0.000138073,0.002392652,0.007935142,0.0002488334,0.004891796,0.00008391625],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929512,0.0008954623,0.0005486649,0.0002414019,0.00007003827,0.001927501,0.001993917,0.00008112125,0.00129061],"genre_scores_gemma":[0.9853157,0.001161621,0.001993638,0.0006832345,0.0001420073,0.002092878,0.00681014,0.00005214678,0.00174872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002499528,"threshold_uncertainty_score":0.01321894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443492215162411,"score_gpt":0.3330471567387479,"score_spread":0.3186122345871238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}