{"id":"W4416140904","doi":"10.1093/neuonc/noaf201.0359","title":"CSIG-25. EXPLORING THE ROLE OF THE CIC/YY1 COMPLEX IN MODULATING SENSITIVITY OF MEK INHIBITORS IN GLIOBLASTOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"MAPK/ERK pathway; Effector; Transcription factor; Suppressor; Kinase; Transcription (linguistics); Downregulation and upregulation; Cell growth; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002310835,0.0003773502,0.0004726419,0.0003405871,0.0001867895,0.0003782531,0.000390675,0.0002776082,0.002453942],"category_scores_gemma":[0.0001068215,0.0001733591,0.0003425874,0.0002833531,0.0002108175,0.0002102957,0.0001958083,0.0005418024,0.0005911024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006628149,"about_ca_system_score_gemma":0.0006232944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002496636,"about_ca_topic_score_gemma":0.00475272,"domain_scores_codex":[0.9998981,0.00001230965,0.000007545649,0.00001648892,0.00002275477,0.00004281642],"domain_scores_gemma":[0.9999489,0.000004456224,0.000008589319,0.000004832041,0.000006533861,0.00002673418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002156446,0.0004509361,0.001635603,0.0003745007,0.0000674528,0.0001343263,0.0000287879,0.0009649014,0.9725394,0.000256891,0.001083631,0.02030723],"study_design_scores_gemma":[0.0005158019,0.008190958,0.02995321,0.00004479316,0.0001949842,0.0004116228,0.00009289753,0.00512448,0.9415678,0.000173405,0.01369183,0.00003829075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842348,0.009331517,0.001136327,0.0002681412,0.00008987182,0.0001955078,0.0018883,0.0001559759,0.002699678],"genre_scores_gemma":[0.992152,0.002850951,0.001104801,0.0001041174,0.00001467936,0.0001024854,0.001644108,0.00001909699,0.00200777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002496636,"threshold_uncertainty_score":0.008209288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992038356312171,"score_gpt":0.2558793208309151,"score_spread":0.2359589372677934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}