{"id":"W4416140939","doi":"10.1093/neuonc/noaf201.0046","title":"EPCO-47. DISSECTING MYC-DRIVEN EPIGENETIC MECHANISMS THAT PROMOTE GROUP 3 MEDULLOBLASTOMA UTILIZING HUMANIZED IPSC MODELS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"H3K4me3; Epigenetics; Medulloblastoma; Neural stem cell; Chromatin; Histone; Polycomb-group proteins; Induced pluripotent stem cell; Effector; PRC2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003184677,0.0003443419,0.0001958666,0.0003999387,0.0002094968,0.0004177042,0.0003499627,0.0005611591,0.003254546],"category_scores_gemma":[0.0001005134,0.0001791328,0.000423625,0.000143531,0.0002581762,0.0002017032,0.0002556801,0.0009682296,0.001002248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003403467,"about_ca_system_score_gemma":0.0002480926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020778,"about_ca_topic_score_gemma":0.001509261,"domain_scores_codex":[0.999796,0.00002333861,0.00002418871,0.00004191637,0.0000794912,0.00003513002],"domain_scores_gemma":[0.999884,0.00001742273,0.00002960291,0.00002503849,0.00001359368,0.00003037961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008264975,0.00007217906,0.0002182908,0.00003456874,0.000007942207,0.00009436098,0.00002592505,0.0002789552,0.9964864,0.0006680641,0.0002365613,0.001794043],"study_design_scores_gemma":[0.00003395247,0.0003201213,0.002103808,0.00001473852,0.00002332631,0.0002912043,0.00002763741,0.002635679,0.9812772,0.0001482712,0.01311853,0.00000557152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9401385,0.001753576,0.03002955,0.0004653487,0.0002227111,0.000486467,0.009086031,0.0007118253,0.01710613],"genre_scores_gemma":[0.9619988,0.001147783,0.01161661,0.0002045274,0.00001704005,0.0004750546,0.00596859,0.0001424136,0.01842914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003254546,"threshold_uncertainty_score":0.0108875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0376564264573605,"score_gpt":0.3122048493021556,"score_spread":0.2745484228447951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}