{"id":"W4416141026","doi":"10.1093/neuonc/noaf201.0119","title":"BIOM-31. PLASMA CELL-FREE DNA METHYLOME PREDICTS RESPONSE TO COMBINED PARP AND IMMUNE CHECKPOINT INHIBITION IN IDH-MUTANT GLIOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Olaparib; Immune checkpoint; DNA methylation; PARP inhibitor; Durvalumab; Glioma; Immune system; Biomarker; Epigenetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002525915,0.0002196956,0.0003286817,0.0003160796,0.0001372283,0.0003889539,0.000179686,0.0003496649,0.002999059],"category_scores_gemma":[0.0006031435,0.0001030602,0.0001803591,0.0002704206,0.0001074208,0.0001825909,0.0002156206,0.0002796692,0.0006484891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552589,"about_ca_system_score_gemma":0.0001637354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007795495,"about_ca_topic_score_gemma":0.001284852,"domain_scores_codex":[0.9998945,0.00002112733,0.00001062821,0.00003692894,0.00002001609,0.00001685888],"domain_scores_gemma":[0.9997464,0.00006133992,0.00008656266,0.0000183023,0.00003368351,0.00005373824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008308966,0.000233745,0.8573221,0.0001818815,0.0002035086,0.0002680065,0.00008480024,0.002062581,0.0797442,0.0001234682,0.002474359,0.04899234],"study_design_scores_gemma":[0.000169975,0.001297965,0.9673949,0.00002447058,0.0001532993,0.001497775,0.0001119713,0.00797837,0.01770222,0.000461501,0.003187205,0.00002046529],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946187,0.0004199118,0.0005976972,0.000125207,0.00001159055,0.00002590268,0.003534826,0.00004725467,0.0006188506],"genre_scores_gemma":[0.9952225,0.00009032785,0.0007610402,0.00006810167,0.000008676018,0.00003095812,0.003243821,0.000007468553,0.0005672115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002999059,"threshold_uncertainty_score":0.01003289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693577264099256,"score_gpt":0.3065460026243378,"score_spread":0.2896102299833452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}