{"id":"W4416141092","doi":"10.1093/neuonc/noaf201.0154","title":"BIOM-66. MODERN MOLECULAR PROFILING RECONTEXTUALIZES THE RTOG-0539 TRIAL AND REVEALS HIDDEN HIGH-RISK AND RADIOTHERAPY RESISTANT MENINGIOMAS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Grading (engineering); Meningioma; Epigenetics; Radiation therapy; Molecular biomarkers; Gene expression profiling; DNA methylation; Adjuvant; Cohort; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003168704,0.000445037,0.0007956056,0.0003603289,0.0002319196,0.000830929,0.0003419617,0.000571661,0.003909024],"category_scores_gemma":[0.002098009,0.0002074281,0.001055206,0.0005685759,0.000273657,0.0004727111,0.0003771177,0.0009797324,0.0007772564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004766908,"about_ca_system_score_gemma":0.0006878449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005645106,"about_ca_topic_score_gemma":0.001501919,"domain_scores_codex":[0.9986482,0.0008657613,0.00009686154,0.0001626441,0.0001273452,0.0000990629],"domain_scores_gemma":[0.999247,0.0001902006,0.0002469367,0.0001669771,0.00004310682,0.0001058985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.3758593,0.002322861,0.09052191,0.002205885,0.006989813,0.0003459934,0.000305855,0.01015283,0.06960592,0.003310345,0.01856646,0.4198128],"study_design_scores_gemma":[0.129434,0.1259677,0.5195772,0.0007210154,0.01116848,0.001244164,0.0003144848,0.02504724,0.03288049,0.01348033,0.1399691,0.0001958916],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700539,0.007809303,0.002977247,0.002935731,0.000347615,0.0007022715,0.005893934,0.0003430341,0.008937006],"genre_scores_gemma":[0.9862007,0.0009576335,0.003244076,0.001177531,0.0001606457,0.0006920446,0.004313864,0.00006697653,0.00318647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003909024,"threshold_uncertainty_score":0.01675791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086159222899891,"score_gpt":0.3046712411534526,"score_spread":0.2838096489244537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}