{"id":"W4416141128","doi":"10.1093/neuonc/noaf201.0209","title":"BIOS-08. TREATMENT STRATEGIES FOR PATIENTS WITH LEPTOMENINGEAL METASTATIC DISEASE (LMD): A NETWORK META-ANALYSIS (NMA) OF RANDOMIZED CONTROLLED TRIALS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Randomized controlled trial; Confidence interval; ThioTEPA; Hazard ratio; Radiation therapy; Meta-analysis; Frequentist inference; Survival analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03003419,0.00296556,0.01098361,0.005781767,0.0005478429,0.003381843,0.002402628,0.002222073,0.01461641],"category_scores_gemma":[0.06184652,0.001218602,0.04386386,0.005578629,0.0008527584,0.002068726,0.002519791,0.002638313,0.001055637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002101469,"about_ca_system_score_gemma":0.002993111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003469287,"about_ca_topic_score_gemma":0.005300904,"domain_scores_codex":[0.9670652,0.02568256,0.002989652,0.002231673,0.001567152,0.0004637704],"domain_scores_gemma":[0.9694743,0.0248586,0.00312474,0.001196713,0.001013341,0.0003323345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.008605547,0.00004464605,0.004920004,0.175976,0.7940432,0.00008747594,0.00008551527,0.001952682,0.0003178878,0.0007895602,0.002921366,0.01025615],"study_design_scores_gemma":[0.006554651,0.0005377525,0.005210439,0.009959135,0.9671528,0.00009406679,0.00006488606,0.002185666,0.0002165833,0.001871237,0.006111136,0.00004159338],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0670465,0.8056839,0.04031451,0.006367153,0.002400903,0.01875614,0.05024669,0.00211977,0.007064417],"genre_scores_gemma":[0.7254748,0.1352548,0.0667631,0.003623541,0.0008270051,0.0457327,0.01742477,0.0008451641,0.004054121],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03003419,"threshold_uncertainty_score":0.1588379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07223634040234676,"score_gpt":0.3764491733524966,"score_spread":0.3042128329501498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}