{"id":"W4416141242","doi":"10.25251/h3w8px06","title":"Efficacy, Safety, and Tolerability of Upadacitinib in Adults and Adolescents With Severe Alopecia Areata: Results From the Randomized, Placebo-Controlled, Double-Blind Phase 3 Program (UP-AA)","year":2025,"lang":"","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; Probity Medical Research; SKiN Health; Queen's University","funders":"Incyte; Les Laboratories Pierre Fabre; National Alopecia Areata Foundation; L'Oreal USA; Sanofi; Pfizer; Concert Pharmaceuticals; Eli Lilly and Company","keywords":"Tolerability; Context (archaeology); Clinical trial; Adverse effect; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001061827,0.0003242182,0.0007935775,0.0001739776,0.0002282064,0.0003962944,0.0002426806,0.0004807835,0.00212664],"category_scores_gemma":[0.0008703595,0.0001486102,0.0007344707,0.0001718972,0.000236222,0.0004222506,0.0001984031,0.001340049,0.0002537859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003424464,"about_ca_system_score_gemma":0.0005138411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481446,"about_ca_topic_score_gemma":0.002038981,"domain_scores_codex":[0.9997032,0.0001445784,0.00002329889,0.00003402116,0.00004821435,0.00004648865],"domain_scores_gemma":[0.9995409,0.0001150866,0.0001388675,0.00002344011,0.00004535468,0.0001363247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5476771,0.04142166,0.01636573,0.001819912,0.001704887,0.0002877899,0.0004301466,0.001007852,0.03540074,0.0002033427,0.005429446,0.3482513],"study_design_scores_gemma":[0.330288,0.516107,0.1375277,0.0002580936,0.001264638,0.0006422763,0.0003087769,0.001341484,0.006888749,0.0001847473,0.005138401,0.00005012059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949049,0.002935908,0.0001827651,0.000164122,0.00004379036,0.0006074047,0.0004195534,0.00002385741,0.0007177548],"genre_scores_gemma":[0.9961002,0.001651198,0.0004874936,0.0003094339,0.00006400222,0.000419653,0.0004416017,0.000005795996,0.0005207343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00212664,"threshold_uncertainty_score":0.007114291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127943142669717,"score_gpt":0.2933219497264348,"score_spread":0.2820425182997376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}