{"id":"W4416141275","doi":"10.1093/neuonc/noaf201.0172","title":"BIOM-84. MGMT METHYLATION STATUS REMAINS LARGELY UNCHANGED IN RECURRENT GLIOMA AND INFLUENCES RE-TREATMENT WITH TEMOZOLOMIDE","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of New Brunswick","funders":"","keywords":"Temozolomide; Methylation; DNA methylation; Cohort; Biomarker; Glioma; Methyltransferase; O-6-methylguanine-DNA methyltransferase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900571,0.0001046416,0.0002673222,0.0003454293,0.0001138473,0.0003432203,0.0001613837,0.0001576789,0.001107857],"category_scores_gemma":[0.001847867,0.0000710087,0.0002084106,0.0004527917,0.0001524529,0.0001461871,0.0001783798,0.0002230435,0.0002420821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004481874,"about_ca_system_score_gemma":0.0003172068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005024598,"about_ca_topic_score_gemma":0.005520925,"domain_scores_codex":[0.9997619,0.00004889514,0.00002191005,0.00006073735,0.00006083996,0.00004579889],"domain_scores_gemma":[0.9994192,0.00008525931,0.0003296732,0.00003199646,0.0000573072,0.00007662021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00149978,0.00005366319,0.9681777,0.00002424554,0.0001160132,0.0001487096,0.0001024854,0.0002887986,0.005988399,0.00003287142,0.0002856886,0.02328173],"study_design_scores_gemma":[0.000006794218,0.0001428951,0.9984167,0.000001770121,0.00002409879,0.0001976124,0.00003992164,0.0002894554,0.0006355901,0.00002199862,0.0002215887,0.000001538192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991909,0.0001473288,0.0000388627,0.00003527153,0.000002011692,0.000002622041,0.0001630659,0.00000514442,0.0004148608],"genre_scores_gemma":[0.9996449,0.00002952992,0.00003167566,0.000009874479,0.000001568575,0.00000191774,0.0001613459,0.000002004772,0.0001171086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005024598,"threshold_uncertainty_score":0.009990752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893829387834275,"score_gpt":0.3345602313429151,"score_spread":0.3056219374645724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}