{"id":"W4416141311","doi":"10.1093/neuonc/noaf201.0246","title":"CNSC-38. TARGETING UNC5B INDUCES BLOOD-BRAIN BARRIER PERMEABILITY AND IMPROVES CHEMOTHERAPY DELIVERY AND EFFICACY IN GLIOBLASTOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Blood–brain barrier; Glioblastoma; Doxorubicin; Drug delivery; Ubiquitin ligase; Central nervous system; Regulator; Stem cell; Targeted drug delivery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003099315,0.0002479066,0.0004272499,0.0002079587,0.000297485,0.0000540164,0.0001577698,0.0002091261,0.00003431014],"category_scores_gemma":[0.002105053,0.0002191931,0.00004853947,0.0004263452,0.0005902711,0.0001621612,0.0002397955,0.0004689338,0.000002224323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004527604,"about_ca_system_score_gemma":0.0001372795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002619931,"about_ca_topic_score_gemma":0.00005233009,"domain_scores_codex":[0.9979327,0.0003816811,0.0003650699,0.0008108976,0.0001305265,0.0003791556],"domain_scores_gemma":[0.997568,0.00196615,0.0001063208,0.0002140526,0.0000444927,0.0001010257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002846422,0.00009438839,0.005071092,0.00002915075,0.00001299545,0.00003503195,0.001387116,0.00000164913,0.9503793,0.0002659814,0.0007892173,0.04164949],"study_design_scores_gemma":[0.005948483,0.001775315,0.05763413,0.00002640837,0.00005927284,0.000115618,0.001191421,0.000253562,0.8003485,0.001380811,0.130785,0.0004814155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926472,0.0004410277,0.00001019581,0.004303436,0.0006721498,0.0003554745,0.000008337637,0.00008019566,0.001482014],"genre_scores_gemma":[0.990082,0.0003139369,0.00006714653,0.009310708,0.00009842094,0.00003315705,3.702743e-7,0.00001589985,0.00007830718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1500307,"threshold_uncertainty_score":0.8938435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292124438302409,"score_gpt":0.2745345270174191,"score_spread":0.261613282634395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}