{"id":"W4416141311","doi":"10.1093/neuonc/noaf201.0246","title":"CNSC-38. TARGETING UNC5B INDUCES BLOOD-BRAIN BARRIER PERMEABILITY AND IMPROVES CHEMOTHERAPY DELIVERY AND EFFICACY IN GLIOBLASTOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Blood–brain barrier; Glioblastoma; Doxorubicin; Drug delivery; Ubiquitin ligase; Central nervous system; Regulator; Stem cell; Targeted drug delivery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252017,0.0003874405,0.000418814,0.0002630762,0.0002014783,0.0001810982,0.0002207957,0.0002225474,0.001082864],"category_scores_gemma":[0.00008235325,0.0001130109,0.0002312208,0.0001989939,0.0002148586,0.000118838,0.0001483292,0.0004315496,0.0002592467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000568992,"about_ca_system_score_gemma":0.0004300292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004717955,"about_ca_topic_score_gemma":0.005787104,"domain_scores_codex":[0.9998927,0.00001061102,0.000008375886,0.00001942948,0.00003168798,0.00003722639],"domain_scores_gemma":[0.9999653,0.000002690601,0.000007411925,0.000004482289,0.000007130345,0.00001300414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003796846,0.0001684146,0.0001547183,0.0001048144,0.00001102452,0.00005204862,0.00002709086,0.0002511338,0.9927798,0.0001058915,0.0002765158,0.005688818],"study_design_scores_gemma":[0.00008642777,0.002285571,0.003879801,0.00001704254,0.00004768941,0.0001972522,0.00003990646,0.002138061,0.9871126,0.00006022691,0.004125224,0.00001033873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948062,0.002230403,0.00118918,0.00009992178,0.00004797895,0.00006679296,0.0003989807,0.00009370808,0.001066723],"genre_scores_gemma":[0.9952782,0.001118339,0.001347449,0.00005606347,0.000005827173,0.00005534466,0.0005692986,0.00001834094,0.001551206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004717955,"threshold_uncertainty_score":0.009380996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292124438302409,"score_gpt":0.2745345270174191,"score_spread":0.261613282634395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}