{"id":"W4416141338","doi":"10.25251/czq0gz98","title":"Rationale and Design of a Phase 1b Trial Evaluating APG279, the Combination of Half-Life-Extended Anti-IL-13 and Anti-OX40L Monoclonal Antibodies, Compared With Dupilumab in Moderate-to-Severe Atopic Dermatitis","year":2025,"lang":"","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dupilumab; Atopic dermatitis; Adverse effect; Monoclonal antibody; Pharmacodynamics; Clinical endpoint; Disease; Incidence (geometry)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01117708,0.002896796,0.002491611,0.0006347558,0.0009578039,0.001820513,0.002006897,0.004169393,0.01555482],"category_scores_gemma":[0.006619922,0.001344749,0.002104269,0.0006292993,0.001847261,0.001731952,0.0008006369,0.005884727,0.005170299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001500636,"about_ca_system_score_gemma":0.005801602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004527885,"about_ca_topic_score_gemma":0.001292939,"domain_scores_codex":[0.9955693,0.002496837,0.0002462601,0.0007792696,0.000452929,0.0004554083],"domain_scores_gemma":[0.9972832,0.0006116508,0.0004788497,0.0002245634,0.0003190922,0.001082562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.7442941,0.0277395,0.007896423,0.01125685,0.00286037,0.001233915,0.0004758013,0.005401308,0.01842188,0.01182986,0.02603794,0.1425519],"study_design_scores_gemma":[0.7084074,0.1864121,0.006851755,0.00186723,0.002355219,0.0007002182,0.0001362455,0.003057495,0.004196956,0.008342983,0.07753208,0.0001402683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.140579,0.02086102,0.01941345,0.0124484,0.00481147,0.7575147,0.009809196,0.0005822893,0.03398045],"genre_scores_gemma":[0.3025874,0.00610448,0.02648048,0.01514659,0.001600549,0.6337066,0.003506239,0.00009165405,0.01077612],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01555482,"threshold_uncertainty_score":0.05911076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03002627146370735,"score_gpt":0.3234356889230727,"score_spread":0.2934094174593653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}