{"id":"W4416141356","doi":"10.1093/neuonc/noaf201.0098","title":"BIOM-10. PREDICTION OF BRAIN METASTASIS DEVELOPMENT FROM LUNG ADENOCARCINOMA USING DNA METHYLOMES AND THEIR NON-INVASIVE DETECTION IN CSF AND PLASMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Thompson Rivers University","funders":"","keywords":"DNA methylation; Nomogram; Cerebrospinal fluid; Adenocarcinoma; Lung cancer; Stage (stratigraphy); Brain metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002192036,0.001058939,0.000596097,0.001547529,0.0002831271,0.0009924949,0.0005175188,0.0006272697,0.001840229],"category_scores_gemma":[0.003905207,0.0002843452,0.001066873,0.0006467024,0.0002399503,0.0004325455,0.0007138613,0.0007563016,0.0007356759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005863495,"about_ca_system_score_gemma":0.0006185751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004443433,"about_ca_topic_score_gemma":0.006632854,"domain_scores_codex":[0.9993194,0.0002533364,0.00006109165,0.0001801241,0.000113726,0.00007228521],"domain_scores_gemma":[0.9976802,0.001400273,0.0003958071,0.0001132545,0.0002257696,0.000184655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001310039,0.0001826113,0.9280027,0.0001315922,0.0005184732,0.00007973056,0.00005533414,0.02305548,0.006466265,0.0001037092,0.001222932,0.03887115],"study_design_scores_gemma":[0.0001014863,0.001290355,0.4689882,0.0000766642,0.0004393341,0.0006586327,0.0001696617,0.5109968,0.01342073,0.001024692,0.002769857,0.00006349578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767507,0.001075618,0.01401451,0.0003661842,0.00004517713,0.00008711193,0.005868297,0.0004905299,0.001301731],"genre_scores_gemma":[0.9888286,0.0001495506,0.005970831,0.00004385887,0.0000176049,0.00005809099,0.004165385,0.00002135548,0.0007447583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004443433,"threshold_uncertainty_score":0.01159275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02482775322553555,"score_gpt":0.28683923490703,"score_spread":0.2620114816814945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}