{"id":"W4416141369","doi":"10.1093/neuonc/noaf201.0312","title":"STEM-04. LONGITUDINAL DNA METHYLATION CHANGE FUELS DISEASE PROGRESSION THROUGH ALTERED CELL STATE DIFFERENTIATION IN IDH-MUTANT GLIOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"DNA methylation; Epigenetics; CpG site; Bisulfite sequencing; Methylation; Glioma; Differentially methylated regions; Epigenetics of physical exercise; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002384276,0.0001552911,0.0002443059,0.0004966718,0.0001778201,0.0004216114,0.0001876569,0.0002097504,0.001919823],"category_scores_gemma":[0.0002674079,0.0001496905,0.0001982137,0.0003342926,0.0002113382,0.0002091308,0.0003153016,0.0002956615,0.0003505019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004694475,"about_ca_system_score_gemma":0.0002922447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00230228,"about_ca_topic_score_gemma":0.003777306,"domain_scores_codex":[0.9999084,0.000006976002,0.000004450307,0.00003512221,0.00002777291,0.00001726315],"domain_scores_gemma":[0.9998362,0.0000207728,0.00005652258,0.00001546621,0.00003171216,0.00003930281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005717556,0.0000563224,0.09001663,0.00007812315,0.00005281562,0.00009160284,0.0002730201,0.0005880991,0.8930339,0.0002514365,0.000277451,0.01470887],"study_design_scores_gemma":[0.00001384294,0.0005959034,0.7055616,0.00001302966,0.0000819409,0.0004527604,0.0003572871,0.00469209,0.2847855,0.0005074358,0.002920807,0.00001778545],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962525,0.0003131971,0.001394006,0.000034959,0.000004802783,0.00001394813,0.001531573,0.00008018674,0.0003748861],"genre_scores_gemma":[0.9964175,0.0001169003,0.0008757425,0.00003023787,0.000001906092,0.000020828,0.001650551,0.00001643215,0.0008699958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00230228,"threshold_uncertainty_score":0.00642252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04711558661739263,"score_gpt":0.3439317110417481,"score_spread":0.2968161244243555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}