{"id":"W4416141370","doi":"10.1093/neuonc/noaf201.0350","title":"CSIG-16. CIC-FUSION ONCOPROTEINS COOPERATE WITH JAK/STAT1/3 SIGNALING TO DRIVE CIC-REARRANGED SARCOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto; University Health Network","funders":"","keywords":"Transcription factor; Effector; Histone; Fusion protein; STAT1; Promoter; Transcription (linguistics); H3K4me3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481482,0.0002485313,0.0002188812,0.0002486387,0.0001484576,0.0003235191,0.0001723721,0.0002863873,0.00161027],"category_scores_gemma":[0.00009343772,0.0001284032,0.0002567405,0.0002226056,0.0002395231,0.0001051372,0.0001753046,0.0005306923,0.0006280342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004463319,"about_ca_system_score_gemma":0.0002434723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006860678,"about_ca_topic_score_gemma":0.001201516,"domain_scores_codex":[0.9998473,0.00002101892,0.00001619938,0.00002185484,0.00004151694,0.00005209069],"domain_scores_gemma":[0.9998952,0.00002024073,0.00002387888,0.00001970324,0.00000512218,0.00003591416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001706609,0.0001046692,0.0009138347,0.00002607457,0.000008397277,0.0001654341,0.00001564232,0.0002436552,0.9964587,0.0002259185,0.0001854587,0.00148149],"study_design_scores_gemma":[0.0000857933,0.0007963041,0.01336567,0.000005109741,0.00002186541,0.001329339,0.00004542351,0.003450209,0.9764435,0.0001250783,0.004326498,0.000005127549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969894,0.0004373763,0.0005310194,0.00008699328,0.00002047862,0.00003234238,0.0005342653,0.00008286854,0.00128533],"genre_scores_gemma":[0.9977021,0.0000915616,0.0004952059,0.00002806873,0.000002309239,0.00001618901,0.0006474928,0.000006761035,0.001010367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00161027,"threshold_uncertainty_score":0.005386949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673949615420703,"score_gpt":0.2984827760712909,"score_spread":0.2817432799170838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}