{"id":"W4416141391","doi":"10.1093/neuonc/noaf201.0331","title":"STEM-24. SINGLE CELL CRISPR/CAS-9 LINEAGE TRACING REVEALS EVOLUTIONARY FITNESS, EXPANSION AND PLASTICITY AXES IN ADULT DIFFUSE GLIOMAS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Lineage (genetic); Transcriptome; Gene; Glioma; Phylogenetic tree; RNA; Gene expression profiling; Phenotype; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819234,0.000140112,0.0001632575,0.0003849535,0.0001334915,0.0003179074,0.0001109032,0.000116563,0.0005065802],"category_scores_gemma":[0.0001825958,0.0001189067,0.0001225814,0.0002692198,0.0001905243,0.0001016163,0.0001311039,0.0001829757,0.0001570244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003085386,"about_ca_system_score_gemma":0.00017661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001891822,"about_ca_topic_score_gemma":0.004360312,"domain_scores_codex":[0.9998966,0.000008251664,0.000008154036,0.0000325834,0.0000385675,0.00001583769],"domain_scores_gemma":[0.9998711,0.00001957991,0.0000559603,0.00001517686,0.0000175615,0.00002067641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000180045,0.00001764,0.02066787,0.00002883692,0.00001255008,0.000105099,0.00007986586,0.0009078545,0.9687043,0.0001810765,0.00004830358,0.009066583],"study_design_scores_gemma":[0.00001243504,0.0003490612,0.2302469,0.000008232222,0.00003690238,0.001175196,0.0001225908,0.01285525,0.7525554,0.0002971127,0.002326191,0.00001470514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950888,0.0001278713,0.003925285,0.000009617473,0.0000010045,0.00001000025,0.0005002393,0.00005801046,0.0002793159],"genre_scores_gemma":[0.995358,0.0001055047,0.00317019,0.000008497925,8.678321e-7,0.00001169095,0.0007938648,0.00001537191,0.0005360264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001891822,"threshold_uncertainty_score":0.003761709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931927797932075,"score_gpt":0.2822541338996811,"score_spread":0.2629348559203604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}