{"id":"W4416141406","doi":"10.1093/neuonc/noaf201.0101","title":"BIOM-13. A GENOME-WIDE IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES BACE1 AS A THERAPEUTIC VULNERABILITY OF LUNG CANCER BRAIN METASTASIS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Concordia University of Edmonton; University of Calgary; Hospital for Sick Children; McMaster University","funders":"","keywords":"Brain metastasis; CRISPR; In vivo; Metastasis; Lung cancer; Cancer; Brain tumor; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003447899,0.0005459428,0.0005371406,0.0006676058,0.0003504992,0.0005450475,0.0004220387,0.0007962298,0.004532363],"category_scores_gemma":[0.0002496766,0.000273496,0.0004291491,0.0002551679,0.0003531321,0.0001598128,0.000433808,0.0008740179,0.0009139042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004602498,"about_ca_system_score_gemma":0.0004556821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456516,"about_ca_topic_score_gemma":0.002419309,"domain_scores_codex":[0.9997069,0.00003980618,0.00002746335,0.00006543232,0.00009961274,0.00006077555],"domain_scores_gemma":[0.9998338,0.00004692834,0.0000354303,0.00001786776,0.0000227568,0.00004320954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000560785,0.00004814468,0.000244758,0.0000450314,0.00001261245,0.0001134009,0.000009523709,0.00009951132,0.9971673,0.0001839275,0.0001747636,0.001844964],"study_design_scores_gemma":[0.00002439887,0.0003729023,0.003425539,0.00001030172,0.0000500945,0.0008580149,0.00002951297,0.001854951,0.9862168,0.0001260446,0.007019874,0.00001159046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.927768,0.002832194,0.04339993,0.0008836998,0.00019506,0.0005859134,0.007135637,0.001865943,0.01533362],"genre_scores_gemma":[0.9632419,0.001167678,0.01486805,0.0003095311,0.0000121834,0.0002204277,0.004992224,0.0001638298,0.01502412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004532363,"threshold_uncertainty_score":0.01516229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02770863832114562,"score_gpt":0.3690529124082874,"score_spread":0.3413442740871417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}