{"id":"W4416141508","doi":"10.1093/neuonc/noaf201.0054","title":"EPCO-55. ALTERNATIVE RNA SPLICING ANALYSIS IDENTIFIES PATTERNS UNDERLYING MALIGNANT TRANSFORMATION AND THERAPEUTIC RESPONSE IN PERIPHERAL NERVE TUMORS","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Selumetinib; Transcriptome; Malignant transformation; Exon; Neurofibromatosis; Alternative splicing; SOX10; Melanoma; Exon skipping","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003069001,0.0001660093,0.000194878,0.0007981497,0.0002940513,0.0004168115,0.0001943259,0.0002787091,0.002198657],"category_scores_gemma":[0.0004975997,0.00009530979,0.0002029183,0.0005220317,0.0002096207,0.0001001809,0.0002036525,0.0002191711,0.0004507132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004227665,"about_ca_system_score_gemma":0.0001775271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002876093,"about_ca_topic_score_gemma":0.006059997,"domain_scores_codex":[0.9997219,0.00002464579,0.00002463104,0.00009458642,0.00008101037,0.00005308662],"domain_scores_gemma":[0.9996176,0.00005997044,0.0001396397,0.0000431705,0.00007182622,0.0000677411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002006256,0.0001343083,0.4633692,0.000164664,0.0001370485,0.0009077591,0.0001873803,0.0005112207,0.5076593,0.0002253845,0.001974759,0.0227227],"study_design_scores_gemma":[0.00002967703,0.0003495847,0.9437371,0.00001809055,0.00008152467,0.002128114,0.0001168594,0.001180197,0.0483836,0.0000724179,0.003892748,0.0000100853],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956568,0.0003736719,0.000518251,0.00004031896,0.000009164527,0.00002113803,0.002393178,0.00003862563,0.00094892],"genre_scores_gemma":[0.9921055,0.0001616912,0.001233656,0.00009057332,0.000007779281,0.00004181768,0.005207419,0.00001973817,0.001131865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002876093,"threshold_uncertainty_score":0.007355273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03727218106995333,"score_gpt":0.3343319514087,"score_spread":0.2970597703387467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}