{"id":"W4416144644","doi":"10.1021/acschemneuro.5c00521","title":"G Protein: β-Arrestin Bias Confers Differential Regulation of Gα <sub>q</sub> Signaling by GPR17 Antagonists","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Multiple Sclerosis Australia","keywords":"Signal transduction; G protein-coupled receptor; HEK 293 cells; Receptor; Endogeny; G protein; Cell signaling; Functional selectivity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430438,0.0001382224,0.0001595635,0.00004818146,0.00005492236,0.00003321698,0.0002705582,0.0001261406,0.000005450569],"category_scores_gemma":[0.000290256,0.0001346073,0.00005732053,0.000230807,0.0001713365,0.000007915726,0.0001230877,0.000109869,6.035429e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001249471,"about_ca_system_score_gemma":0.00007043463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006910312,"about_ca_topic_score_gemma":7.025823e-7,"domain_scores_codex":[0.9987684,0.00004668145,0.0002896262,0.0004534994,0.0001945766,0.0002472174],"domain_scores_gemma":[0.9995578,0.00001982858,0.000103804,0.0002092607,0.00005184429,0.00005744028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004769811,0.00005669997,0.0002415308,0.000022868,0.000001738402,8.565445e-7,0.000006694388,0.00004612247,0.9984854,0.0002091486,0.0001213803,0.0007597996],"study_design_scores_gemma":[0.0003211666,0.00006149251,0.0002722468,0.00005316722,0.000004594364,0.000001466635,0.00000650182,0.0006051954,0.9981125,0.0002074797,0.0002311805,0.0001230226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944705,0.00004182644,0.004957856,0.00009017124,0.0001649112,0.0001971127,0.000008958546,0.00001040457,0.00005829664],"genre_scores_gemma":[0.9995702,0.00001635222,0.0001476491,0.0001315251,0.00003339718,0.00001593676,0.00002947777,0.000009421139,0.00004606253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005099716,"threshold_uncertainty_score":0.5489126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253176580904478,"score_gpt":0.2361758411343569,"score_spread":0.2236440753253121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}