{"id":"W4416146378","doi":"10.1016/s2215-0366(25)00296-2","title":"Efficacy and safety of iclepertin for cognitive impairment associated with schizophrenia (CONNEX programme): results from three phase 3 randomised controlled trials","year":2025,"lang":"en","type":"article","venue":"The Lancet Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Schizophrenia (object-oriented programming); Cognitive impairment; MEDLINE; Phase (matter); Cognition; Randomized controlled trial; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003506657,0.0002802845,0.002184671,0.0001008635,0.0001771114,0.00004216658,0.0001420256,0.0001061715,0.00002528459],"category_scores_gemma":[0.006110003,0.0001360141,0.0003400395,0.0002609701,0.0002048206,0.00003420032,0.00003644094,0.0002344094,0.000002027639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005416598,"about_ca_system_score_gemma":0.0006743186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007371041,"about_ca_topic_score_gemma":0.0007491968,"domain_scores_codex":[0.9973292,0.0005080433,0.0009753147,0.0004042724,0.0003204203,0.0004627855],"domain_scores_gemma":[0.9912253,0.007416773,0.0005304219,0.0004259012,0.0002450701,0.0001565568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9610558,0.001979647,0.004499981,0.00005215804,0.00659386,0.000004791916,0.0001174026,0.000001123328,0.0001447683,0.000959515,0.001044859,0.02354613],"study_design_scores_gemma":[0.9219047,0.003175922,0.06282737,0.001316345,0.002997139,0.000002286514,0.0001943606,0.0005031752,0.0006266988,0.006287287,0.00003272117,0.0001319617],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964881,0.002589191,0.0005885901,0.01764539,0.0001770672,0.01251169,0.001097365,0.00008191227,0.0004277969],"genre_scores_gemma":[0.9939405,0.0001451287,0.0036353,0.0003326092,0.0004131639,0.00098633,0.0004344265,0.00002267804,0.00008983957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05832739,"threshold_uncertainty_score":0.7314686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05022223329807997,"score_gpt":0.3574219514639798,"score_spread":0.3071997181658999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}