{"id":"W4416160559","doi":"10.1016/j.fander.2025.09.597","title":"Icotrokinra, peptide oral ciblé bloquant sélectivement le récepteur de l’interleukine-23, pour le traitement du psoriasis en plaque modéré à sévère: résultats jusqu’à la semaine 24 de l’essai de phase 3 ICONIC-LEAD","year":2025,"lang":"fr","type":"article","venue":"Annales de Dermatologie et de Vénéréologie - FMC","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Psoriasis; Plaque psoriasis; Chemotherapy; Clinical Practice","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008527255,0.0007651697,0.001092866,0.0002622218,0.0003556679,0.000602957,0.00050664,0.0007037809,0.003488228],"category_scores_gemma":[0.0003958336,0.0002498438,0.001034834,0.0002625861,0.0006075117,0.0005386031,0.0002662381,0.001673101,0.0006648417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004120845,"about_ca_system_score_gemma":0.0005518668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00206257,"about_ca_topic_score_gemma":0.002423818,"domain_scores_codex":[0.9996451,0.0001084097,0.00001632159,0.00004128722,0.00005762747,0.0001311411],"domain_scores_gemma":[0.9997343,0.00007648112,0.00003046203,0.00004477488,0.00002616208,0.00008770335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2140741,0.07080678,0.003822143,0.001262628,0.001742853,0.001289481,0.0006861154,0.003051105,0.427306,0.000863407,0.007754705,0.2673406],"study_design_scores_gemma":[0.09833542,0.6308033,0.01839792,0.0001372172,0.001727639,0.002093163,0.0003309778,0.00183236,0.2228257,0.0004907028,0.02293526,0.00009034141],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860183,0.007842352,0.001417356,0.0003764372,0.0002341649,0.0006373306,0.0006304236,0.00008210183,0.002761528],"genre_scores_gemma":[0.985797,0.004685758,0.001766538,0.0005210326,0.0001291973,0.0003666314,0.001728814,0.00005887393,0.004946091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003488228,"threshold_uncertainty_score":0.01166922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102614604849193,"score_gpt":0.3170725155833248,"score_spread":0.2860463695348329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}