{"id":"W4416166919","doi":"10.3324/haematol.2025.287443","title":"Novel and emerging therapeutic strategies for clonal haematopoiesis","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epigenetics; Haematopoiesis; Bone marrow; Somatic evolution in cancer; Stem cell; Epigenesis; Leukemia; Hematopoietic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006396893,0.0005335377,0.0007065187,0.0008119374,0.0003110239,0.001029891,0.0006782712,0.000877386,0.005172136],"category_scores_gemma":[0.0005786568,0.0001322321,0.0006133704,0.0003414132,0.0004594609,0.0009625765,0.0008425834,0.00262376,0.0009673219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004416647,"about_ca_system_score_gemma":0.0006543962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003023971,"about_ca_topic_score_gemma":0.001091771,"domain_scores_codex":[0.9997388,0.00006990824,0.00002023363,0.00003798417,0.00008114434,0.00005187703],"domain_scores_gemma":[0.9998131,0.00006144157,0.0000393049,0.0000119094,0.00003964201,0.00003451783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005560658,0.0005529462,0.0008877334,0.005726693,0.0002538506,0.00120032,0.0002265697,0.001329818,0.04067437,0.03230955,0.03522302,0.8810591],"study_design_scores_gemma":[0.0003637052,0.0011986,0.002017684,0.001921611,0.0002821965,0.003693172,0.0002213843,0.001339803,0.0145132,0.01855757,0.9558478,0.00004325192],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01326243,0.9407117,0.01762208,0.009252029,0.002035813,0.0001800401,0.000244236,0.0003295517,0.01636211],"genre_scores_gemma":[0.127709,0.8306503,0.01894395,0.007830095,0.002633212,0.0003597913,0.0007616832,0.00007429677,0.01103773],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005172136,"threshold_uncertainty_score":0.01730251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390705616631437,"score_gpt":0.3530496653519271,"score_spread":0.3091426091856127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}