{"id":"W4416166919","doi":"10.3324/haematol.2025.287443","title":"Novel and emerging therapeutic strategies for clonal haematopoiesis","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epigenetics; Haematopoiesis; Bone marrow; Somatic evolution in cancer; Stem cell; Epigenesis; Leukemia; Hematopoietic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236642,0.0001567964,0.0004367812,0.0001599413,0.0001805811,0.00005495795,0.0001172707,0.0001366339,0.0000824482],"category_scores_gemma":[0.0001522528,0.0001141129,0.00008774881,0.0002280206,0.0001972347,0.0000753846,0.0000939646,0.000184183,0.00001005263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005517559,"about_ca_system_score_gemma":0.0003118893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002282737,"about_ca_topic_score_gemma":0.000008802752,"domain_scores_codex":[0.9989328,0.00002369261,0.0002337587,0.0003137017,0.0001495975,0.0003464113],"domain_scores_gemma":[0.9991742,0.0003469744,0.00004454457,0.0002402847,0.0001185704,0.00007544909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001254904,0.0003310475,0.008915342,0.002282387,0.0006614805,0.0001927769,0.0006903588,0.00000754134,0.04151443,0.90522,0.01713726,0.0217925],"study_design_scores_gemma":[0.03442987,0.003043439,0.160822,0.002442045,0.002103747,0.00950096,0.03515897,0.03242616,0.05824671,0.3326677,0.3266552,0.002503142],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8063953,0.005047063,0.1205418,0.03305846,0.0002284903,0.002263955,0.00003061787,0.0003981774,0.03203611],"genre_scores_gemma":[0.9845142,0.0001232987,0.0117197,0.001808803,0.00003339637,0.0001876703,0.00001247256,0.00001475194,0.00158574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5725523,"threshold_uncertainty_score":0.4653389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390705616631437,"score_gpt":0.3530496653519271,"score_spread":0.3091426091856127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}