{"id":"W4416168641","doi":"10.1128/mbio.02227-25","title":"Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; McMaster University; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Enzyme; Extracellular; Bacteria; Secretion; Guanosine; Intracellular; Cytoplasm; Adenosine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005405586,0.0005147193,0.0003077035,0.0002161892,0.0001060177,0.0004632001,0.00008653817,0.0002402783,0.001005924],"category_scores_gemma":[0.0001908348,0.0001031047,0.0003134329,0.000155926,0.0001176121,0.0002151446,0.0004044373,0.0002877152,0.0009972465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000124502,"about_ca_system_score_gemma":0.0001296698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000346821,"about_ca_topic_score_gemma":0.0002362565,"domain_scores_codex":[0.9999096,0.000007727036,0.00001031289,0.00002260762,0.00002831964,0.00002128573],"domain_scores_gemma":[0.9998224,0.00002372038,0.000055319,0.00002341909,0.00002786653,0.00004723073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006130109,0.0000135693,0.002921284,0.0000529534,0.000006740564,0.0002026094,0.00002288335,0.00004399694,0.9930698,0.00009420144,0.0001303765,0.003380188],"study_design_scores_gemma":[0.00001930359,0.0002263003,0.04226241,0.00002053779,0.00002603534,0.001508957,0.0001521661,0.001614827,0.9457662,0.0002171811,0.008171621,0.00001460521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888763,0.001934464,0.005364406,0.0001239853,0.00006907716,0.00002302434,0.0009794254,0.000591507,0.00203769],"genre_scores_gemma":[0.9914531,0.0006131658,0.003734665,0.00009235876,0.00002482377,0.00001323655,0.001543234,0.00003582096,0.002489623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005924,"threshold_uncertainty_score":0.003365159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008222200918201012,"score_gpt":0.2236856768157811,"score_spread":0.2154634758975801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}