{"id":"W4416186290","doi":"10.1093/clinchem/hvaf162","title":"Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?","year":2025,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Olav Thon Stiftelsen; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Göteborgs Universitet; Hjärnfonden; Fondation Brain Canada; Knut och Alice Wallenbergs Stiftelse; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Lunds Universitet; Canadian Institutes of Health Research; Weston Brain Institute; GHR Foundation; Alzheimer's Association; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Alzheimer's Drug Discovery Foundation","keywords":"Value (mathematics); Predictive value; Plasma levels; Disease; Alzheimer's disease; Blood plasma; Plasma concentration","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0213764,0.0008369221,0.001421399,0.001174128,0.0004341907,0.002550552,0.001247162,0.001527032,0.0008994148],"category_scores_gemma":[0.04616514,0.0003737258,0.0005617978,0.001273288,0.002075166,0.001691446,0.0009750666,0.001255089,0.0005926602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006410262,"about_ca_system_score_gemma":0.0008276204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009201698,"about_ca_topic_score_gemma":0.001305405,"domain_scores_codex":[0.9895948,0.005517321,0.0008775374,0.001731475,0.001974209,0.0003045774],"domain_scores_gemma":[0.9772817,0.01326119,0.003546115,0.001533249,0.003704185,0.0006736275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004319863,0.0002163664,0.7433832,0.001070177,0.001299246,0.0006250812,0.0011195,0.001647039,0.0247827,0.002021757,0.003668838,0.2158462],"study_design_scores_gemma":[0.0004332396,0.005110565,0.813179,0.002594598,0.002426701,0.008525505,0.002033348,0.04284119,0.07122894,0.02585899,0.02551753,0.0002503707],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.861181,0.07926123,0.04341093,0.007572836,0.001084933,0.000142912,0.0006646856,0.0003654058,0.006316079],"genre_scores_gemma":[0.9770692,0.003538446,0.01683988,0.001377949,0.0004366871,0.00006994394,0.0002494298,0.00004118692,0.0003772173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0213764,"threshold_uncertainty_score":0.1130506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0922425723317202,"score_gpt":0.450465628520792,"score_spread":0.3582230561890718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}