{"id":"W4416192053","doi":"10.1016/j.jaci.2025.08.034","title":"Targeting IL-22RA1 with temtokibart: A novel approach in atopic dermatitis: Phase 2a monotherapy study results","year":2025,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Queen's University; Lynde Centre for Dermatology; University of Toronto","funders":"LEO Pharma; LEO Pharma Research Foundation","keywords":"Phase (matter); Disease; Clinical trial; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262993,0.00100682,0.001713532,0.0003004611,0.0002608302,0.0008018735,0.0006062288,0.001090936,0.003191333],"category_scores_gemma":[0.0004682623,0.0003206435,0.001292873,0.0002216766,0.000323095,0.0006037197,0.0002119894,0.001910511,0.0008041215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000465625,"about_ca_system_score_gemma":0.0007137232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003852504,"about_ca_topic_score_gemma":0.001337263,"domain_scores_codex":[0.9996923,0.0001165792,0.00002346227,0.00005821751,0.00005536262,0.00005406374],"domain_scores_gemma":[0.9997012,0.00005472134,0.00006296796,0.00002769157,0.00004036523,0.000113056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3547356,0.09150102,0.005529429,0.003984505,0.004640484,0.0006266652,0.0004089659,0.00287358,0.198642,0.0004813491,0.01153459,0.3250418],"study_design_scores_gemma":[0.5074861,0.4423034,0.01909926,0.0002209152,0.002081672,0.0009879995,0.00008595119,0.002179982,0.0144794,0.0002937976,0.01071919,0.00006222469],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776618,0.01357989,0.00148196,0.0009303972,0.0002504451,0.002209476,0.001554704,0.000167193,0.002164176],"genre_scores_gemma":[0.9727183,0.01055369,0.004415203,0.002016164,0.0003697925,0.00390649,0.002202524,0.00005729576,0.003760525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003191333,"threshold_uncertainty_score":0.01067603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505181829622308,"score_gpt":0.3506490835011474,"score_spread":0.3255972652049243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}