{"id":"W4416192874","doi":"10.1021/acsptsci.5c00499","title":"Longitudinal Plasma Multiomics Characterization of Nephrotoxicity in Beagles Following Repeated Dosing of Enteric-Coated Propyl Gallate Tablets","year":2025,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bruker (Canada)","funders":"AstraZeneca","keywords":"Nephrotoxicity; Lipidome; Lipid metabolism; Toxicity; Oxidative stress; Dosing; Kidney; Lipid peroxidation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004479508,0.0003625073,0.0005801647,0.0004185436,0.0001834182,0.0004066913,0.0001778236,0.0005499207,0.00062356],"category_scores_gemma":[0.0004521868,0.0001718025,0.0003472096,0.0002906082,0.0003628783,0.0003916413,0.0002247594,0.0008034226,0.0001692727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523741,"about_ca_system_score_gemma":0.00021032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006806714,"about_ca_topic_score_gemma":0.0008707307,"domain_scores_codex":[0.9997736,0.00003419505,0.0000113881,0.00008094373,0.00006997051,0.00002987989],"domain_scores_gemma":[0.9997066,0.00003550557,0.0001079941,0.00002780021,0.00006185164,0.00006033375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003090321,0.0002220895,0.01047692,0.00008795674,0.0001173207,0.0001440332,0.0001040334,0.0002013317,0.9801857,0.00006888211,0.0002451534,0.005056162],"study_design_scores_gemma":[0.0001662122,0.01336174,0.3023499,0.00003228771,0.0006359678,0.001197286,0.0003727013,0.005788727,0.6691102,0.0004602835,0.006435024,0.00008960098],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947668,0.0007909078,0.003070919,0.0001007717,0.00001897043,0.0000655756,0.0008204536,0.00005603439,0.000309501],"genre_scores_gemma":[0.9920964,0.0008699815,0.003106369,0.0003413534,0.00002123695,0.0001649621,0.001714679,0.00003862164,0.001646269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006806714,"threshold_uncertainty_score":0.002368987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05770100027750049,"score_gpt":0.4073432900688589,"score_spread":0.3496422897913584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}