{"id":"W4416194118","doi":"10.1001/jamaoncol.2025.4543","title":"Immune Checkpoint Inhibitor–Associated Cardiovascular Toxic Effects","year":2025,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Toronto General Hospital; Population Health Research Institute","funders":"","keywords":"Myocarditis; Pericarditis; Cardiotoxicity; Disease; Cancer; Acute pericarditis; Heart disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008030104,0.0001604922,0.0006677849,0.0001594924,0.0000825012,0.00001582462,0.0001038181,0.0004050667,0.0001028441],"category_scores_gemma":[0.000394655,0.0001395971,0.0006683348,0.0004541744,0.0001214515,0.00004415709,0.00006533664,0.0003261041,0.00004348661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008869737,"about_ca_system_score_gemma":0.0004365142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002793078,"about_ca_topic_score_gemma":0.00003932687,"domain_scores_codex":[0.9986451,0.0002045181,0.000371347,0.0002809708,0.0001830198,0.0003150793],"domain_scores_gemma":[0.9991382,0.0001946777,0.00008515994,0.0004199107,0.0001008088,0.00006119987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004343666,0.0009242867,0.003647043,0.0004443941,0.006952634,0.000574542,0.0004521402,0.000005301504,0.3990917,0.0001810889,0.02366156,0.5597216],"study_design_scores_gemma":[0.01828724,0.001484543,0.2051985,0.0004744397,0.0006900664,0.00007679645,0.0001285823,0.00004473207,0.130602,0.0001595101,0.6426445,0.0002090281],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9238559,0.02268698,0.0001566944,0.008482334,0.002321466,0.0008504335,0.000004381645,0.0001751261,0.04146671],"genre_scores_gemma":[0.9916082,0.0006196447,0.0001462489,0.003491744,0.0002524195,0.00009454008,0.00002817781,0.00001894283,0.003740051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.618983,"threshold_uncertainty_score":0.5692606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008894360964312868,"score_gpt":0.2788533286064106,"score_spread":0.2699589676420978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}