{"id":"W4416196508","doi":"10.1016/j.forc.2025.100710","title":"Differentiation of methyl-substituted fentanyl analogs using optimized weighting within the inverted library search algorithm (ILSA)","year":2025,"lang":"en","type":"article","venue":"Forensic Chemistry","topic":"Forensic Toxicology and Drug Analysis","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trent University","funders":"National Institute of Justice","keywords":"Weighting; Fentanyl; Fragmentation (computing); A-weighting; Similarity (geometry); Homogeneous","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007206186,0.0007048976,0.00100348,0.001723985,0.0005185755,0.001163227,0.0007547954,0.0005378379,0.004141981],"category_scores_gemma":[0.002190175,0.0002463085,0.001029262,0.001273426,0.0002035785,0.0008398872,0.0009604947,0.00063555,0.001478791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003396259,"about_ca_system_score_gemma":0.001719189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003649516,"about_ca_topic_score_gemma":0.006976304,"domain_scores_codex":[0.999582,0.00006947302,0.00004563614,0.00009328604,0.0001460501,0.00006352426],"domain_scores_gemma":[0.999481,0.0001697993,0.00006147671,0.00003497934,0.0002194037,0.00003341672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001977265,0.000478458,0.007613786,0.0006882071,0.0002388103,0.0004514598,0.0001527465,0.04379334,0.215373,0.005283735,0.003509157,0.72044],"study_design_scores_gemma":[0.0001555998,0.001018942,0.004708527,0.00005456683,0.0003053996,0.0007443306,0.0001718562,0.8233213,0.1564218,0.003390008,0.009610915,0.00009671718],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4300632,0.004251368,0.5488715,0.0003053934,0.0001508508,0.0003673462,0.002180758,0.003985924,0.009823797],"genre_scores_gemma":[0.484742,0.0008341025,0.50398,0.0001933939,0.00004379756,0.0002116153,0.004070283,0.0004087894,0.005515979],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004141981,"threshold_uncertainty_score":0.01385635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05267850947248979,"score_gpt":0.3693136669529713,"score_spread":0.3166351574804815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}