{"id":"W4416196978","doi":"10.1523/jneurosci.1353-25.2025","title":"The Neuromuscular Junction: A Shared Vulnerability in Aging and Disease","year":2025,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; Genentech; Insmed; University of Pittsburgh; Brown University","keywords":"Amyotrophic lateral sclerosis; Neuromuscular junction; Neuromuscular transmission; Disease; Postsynaptic potential; Synapse; Motor neuron; Muscle weakness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005352668,0.0004092636,0.0008687981,0.0006540063,0.0004139582,0.001092143,0.000321446,0.0009657172,0.0009535849],"category_scores_gemma":[0.000555351,0.0001266714,0.0003244247,0.0004317982,0.0007674317,0.001153978,0.001218355,0.0008782754,0.0003437025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003964202,"about_ca_system_score_gemma":0.0006288865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006528115,"about_ca_topic_score_gemma":0.001009879,"domain_scores_codex":[0.9997422,0.00004281521,0.00003299658,0.0000768415,0.00007001944,0.00003508373],"domain_scores_gemma":[0.9997999,0.00004041995,0.00006323845,0.00001334304,0.00004608512,0.00003692967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007688092,0.0000768139,0.028048,0.007728845,0.000580352,0.01088823,0.002937271,0.0005643424,0.1944262,0.03457284,0.01485153,0.7045568],"study_design_scores_gemma":[0.00005645789,0.001519229,0.2355313,0.005743274,0.001046432,0.08598565,0.003502349,0.0009781143,0.02816128,0.05868055,0.5785997,0.0001957101],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06069192,0.9216444,0.005242939,0.005424559,0.0008777938,0.00002441867,0.0002025556,0.0001253766,0.005766035],"genre_scores_gemma":[0.3451163,0.6392194,0.004912604,0.002793392,0.001696213,0.0000640171,0.0003130017,0.00003702892,0.005848058],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001092143,"threshold_uncertainty_score":0.003190041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03565605920437875,"score_gpt":0.3372849845979373,"score_spread":0.3016289253935586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}