{"id":"W4416216601","doi":"10.1182/blood.2025028933","title":"Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Amgen (Canada); University of Toronto; University Health Network; Princess Margaret Cancer Centre; McMaster University","funders":"Princess Margaret Cancer Foundation; Cancer Center, University of Colorado; Genome Canada; University of Cincinnati; National Institutes of Health; Cincinnati Children's Hospital Medical Center; Celgene; Rally Foundation; V Foundation for Cancer Research; Elsa U. Pardee Foundation","keywords":"Mitochondrial permeability transition pore; Mitochondrion; Glutaredoxin; Oxidative phosphorylation; Myeloid leukemia; Haematopoiesis; Inner mitochondrial membrane; Glutathione; ATP synthase; mitochondrial fusion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007241,0.0002757911,0.0002068512,0.0001290316,0.0001553539,0.0002765745,0.0001625438,0.0002509666,0.001140883],"category_scores_gemma":[0.0001060164,0.00008084165,0.0002324999,0.00013459,0.0001940965,0.0001599383,0.0002778812,0.0003194703,0.0003864673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455436,"about_ca_system_score_gemma":0.0001625632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002696616,"about_ca_topic_score_gemma":0.000296494,"domain_scores_codex":[0.9999158,0.00001021683,0.000009942535,0.00002505395,0.00002208308,0.00001698909],"domain_scores_gemma":[0.9999229,0.000007167894,0.00003378309,0.000009189516,0.000007980267,0.00001906785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001751301,0.00001331597,0.001175443,0.00004437134,0.00001043615,0.000161113,0.00001174761,0.00005169548,0.9970071,0.0001124106,0.0000844302,0.001152812],"study_design_scores_gemma":[0.00004103035,0.0002501915,0.03246679,0.00001523624,0.0000595563,0.001547516,0.00005479173,0.001373227,0.9589446,0.000219139,0.00502051,0.000007361107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925034,0.002286184,0.003446535,0.0002498112,0.00004599236,0.0000195314,0.0005968167,0.0001737849,0.000677958],"genre_scores_gemma":[0.9974505,0.0004405043,0.0006180716,0.00004985842,0.000005768884,0.000008508679,0.0005320291,0.0000101251,0.0008845887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140883,"threshold_uncertainty_score":0.003816664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008244670536948372,"score_gpt":0.2721798467404309,"score_spread":0.2639351762034826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}